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Editorial
. 2019 Feb;73(2):281-284.
doi: 10.1053/j.ajkd.2018.08.009. Epub 2018 Oct 18.

ARNT as a Novel Antifibrotic Target in CKD

Volker H Haase  1
Affiliations
Editorial

ARNT as a Novel Antifibrotic Target in CKD

Volker H Haase. Am J Kidney Dis. 2019 Feb.
No abstract available

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Figures

Figure 1.
Figure 1.
The 12-kDa FK506-binding protein/ying yang 1/aryl hydrocarbon receptor nuclear translocator/activin receptor-like kinase 3 (FKBP12/YY1/ARNT/ALK3) axis in renoprotection. Schematic overview of the proposed mechanism underlying FK506-induced renoprotection. FK506 and GPI-1046 disrupt the formation of the FKBP12/YYI transcriptional suppressor complex that inhibits ARNT transcription. This leads to de-repression of ARNT transcription, increased cellular ARNT levels, and ARNT homodimerization with subsequent increase in ALK3 transcription. ALK3 has renoprotective properties. Shown is also the core DNA binding sequence (E-box) for ARNT homodimers found in the ALK3 promoter region.
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References

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