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. 2018 Sep-Oct;34(5):1209-1214.
doi: 10.12669/pjms.345.15739.

Vitamin D levels in patients with ankylosing spondylitis: Is it related to disease activity?

Burhan Fatih Kocyigit  1 , Ahmet Akyol  2
Affiliations

Vitamin D levels in patients with ankylosing spondylitis: Is it related to disease activity?

Burhan Fatih Kocyigit et al. Pak J Med Sci. 2018 Sep-Oct.

Abstract

Objective: Ankylosing Spondylitis (AS) is an inflammatory rheumatic disease that mainly affects the axial spine. Osteopenia and osteoporosis are the main complications of AS. Vitamin D has functions on the immune system. In this study, we aimed to compare vitamin D levels and Bone Mineral Density (BMD) values between AS patients and controls.

Methods: A total of 68 patients with axial AS and 34 healthy controls were enrolled in this study conducted between March 2018 and May 2018. Vitamin D concentrations, BMD values, disease activity, back mobility, functionality and radiologic damage were evaluated.

Results: Vitamin D concentrations, the total BMD-femur and BMD-femur neck values were significantly lower in AS patients (p = 0.001, p = 0.011 and p = 0.003). No significant correlations were detected between vitamin D levels and BMD-femur total, BMD-femur neck values, disease activity, back mobility, functionality and radiologic damage scores (p > 0.05). Disease activity parameters were significantly and negatively correlated with total BMD-femur and BMD-femur neck values (p < 0.05).

Conclusion: Our study demonstrates that AS patients have lower vitamin D levels, total BMD-femur and BMD-femur neck values. Higher disease activity increases bone loss in AS. Regular measurement of BMD and vitamin D should be kept in mind when planning a treatment in AS.

Keywords: Ankylosing Spondylitis; Bone bineral density; Disease activity; Vitamin D.

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References

    1. Dougados M, Baeten D. Spondyloarthritis. Lancet. 2011;377(9783):2127–2137. doi:10.1016/S0140-6736(11)60071-8. - PubMed
    1. Elewaut D, Matucci-Cerinic M. Treatment of ankylosing spondylitis and extra-articular manifestations in everyday rheumatology practice. Rheumatol (Oxford) 2009;48(9):1029–1035. doi:10.1093/rheumatology/kep146. - PubMed
    1. Ghozlani I, Ghazi M, Nouijai A, Mounach A, Rezqi A, Achemlal L, et al. Prevalence and risk factors of osteoporosis and vertebral fractures in patients with ankylosing spondylitis. Bone. 2009;44(5):772–776. doi:10.1016/j.bone.2008.12.028. - PubMed
    1. Vosse D, Landewe R, van der Heijde D, van der Linden S, van Staa TP, Geusens P. Ankylosing spondylitis and the risk of fracture:results from a large primary care-based nested case control study. Ann Rheum Dis. 2009;68(12):1839–1842. doi:10.1136/ard.2008.100503. - PubMed
    1. Franck H, Meurer T, Hofbauer LC. Evaluation of bone mineral density, hormones, biochemical markers of bone metabolism and osteoprotegerin serum levels in patients with ankylosing spondylitis. J Rheumatol. 2004;31(11):2236–2241. - PubMed

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