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. 1977:88:309-18.
doi: 10.1007/978-1-4613-4169-7_29.

Genetic and cellular control of spontaneous autoimmune thyroiditis in OS chickens

L D Bacon, R S Sundick, N R Rose

Genetic and cellular control of spontaneous autoimmune thyroiditis in OS chickens

L D Bacon et al. Adv Exp Med Biol. 1977.

Abstract

B-locus genotypes have been defined in Obese strain (OS) chickens that spontaneously develop autoimmune thyroiditis (SAT), and in White Leghorn Cornell C strain (CS) chickens from which the OS was selected. The B-locus influences SAT, and some possible mechanisms are discussed. Thymic abnormalities in OS, as contrasted with CB birds, are also discussed and may play a role in SAT, as may an intrinsic defect in the thyroid gland itself.

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