Acute-on-Chronic Liver Failure

Christian M Lange¹, Wolf Otto Bechstein², Thomas Berg³, Cornelius Engelmann³, Tony Bruns⁴, Ali Canbay⁵, Richard Moreau⁶, Jonel Trebicka^{7

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Affiliations

¹ Department of Gastroenterology and Hepatology, University Hospital Essen, Essen, Germany.
² Department of General and Visceral Surgery, Goethe-University Hospital Frankfurt, Frankfurt/M., Germany.
³ Department of Gastroenterology, Rheumatology and Hepatology, University Hospital Leipzig, Leipzig, Germany.
⁴ Department of Internal Medicine IV, University Hospital Jena, Jena, Germany.
⁵ Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Magdeburg A.ö.R., Magdeburg, Germany.
⁶ Centre de Recherche sur l'Inflammation (CRI), Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris-Diderot, Paris, France.
⁷ European Foundation for the Study of Chronic Liver Failure, Barcelona, Spain.
⁸ Department of Internal Medicine I, University of Bonn, Bonn, Germany.
⁹ Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
¹⁰ Institute for Bioengineering of Catalonia, Barcelona, Spain.

Review

Christian M Lange et al. Visc Med. 2018 Aug.

. 2018 Aug;34(4):296-300.

doi: 10.1159/000491406. Epub 2018 Jul 12.

Christian M Lange¹, Wolf Otto Bechstein², Thomas Berg³, Cornelius Engelmann³, Tony Bruns⁴, Ali Canbay⁵, Richard Moreau⁶, Jonel Trebicka^{7

8

9

10}

¹ Department of Gastroenterology and Hepatology, University Hospital Essen, Essen, Germany.
² Department of General and Visceral Surgery, Goethe-University Hospital Frankfurt, Frankfurt/M., Germany.
³ Department of Gastroenterology, Rheumatology and Hepatology, University Hospital Leipzig, Leipzig, Germany.
⁴ Department of Internal Medicine IV, University Hospital Jena, Jena, Germany.
⁵ Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Magdeburg A.ö.R., Magdeburg, Germany.
⁶ Centre de Recherche sur l'Inflammation (CRI), Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris-Diderot, Paris, France.
⁷ European Foundation for the Study of Chronic Liver Failure, Barcelona, Spain.
⁸ Department of Internal Medicine I, University of Bonn, Bonn, Germany.
⁹ Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
¹⁰ Institute for Bioengineering of Catalonia, Barcelona, Spain.

No abstract available

References

1. Moreau R, Jalan R, Gines P, et al. Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis. Gastroenterology. 2013;144:1426–1437. 1437.e1–9. - PubMed
1. Fernández J, Acevedo J, Wiest R, et al., European Foundation for the Study of Chronic Liver Failure Bacterial and fungal infections in acute-on-chronic liver failure: prevalence, characteristics and impact on prognosis. Gut. 2017 DOI: 10.1136/gutjnl-2017-314240. - PubMed
1. Moreau R, Elkrief L, Bureau C, et al. A randomized trial of 6-month norfloxacin therapy in patients with Child-Pugh class C cirrhosis. J Hepatol. 2017;66((suppl)):S1.
1. Gustot T, Fernandez J, Garcia E, et al., CANONIC Study Investigators of the EASL-CLIF Consortium Clinical course of acute-on-chronic liver failure syndrome and effects on prognosis. Hepatology. 2015;62:243–252. - PubMed
1. Artru F, Louvet A, Ruiz I, et al. Liver transplantation in the most severely ill cirrhotic patients: a multicentre study in acute-on-chronic liver failure grade 3. J Hepatol. 2017;67:708–715. - PubMed