Dysbiosis of the gut microbiota and colorectal cancer: the key target of molecular pathological epidemiology

Keisuke Kosumi^{1

2}, Kosuke Mima^{1

2}, Hideo Baba², Shuji Ogino^{1

3

4

5}

Affiliations

¹ Department of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
² Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan.
³ Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
⁴ Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
⁵ Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Comment

Keisuke Kosumi et al. J Lab Precis Med. 2018 Sep.

. 2018 Sep:3:76.

doi: 10.21037/jlpm.2018.09.05. Epub 2018 Sep 25.

Keisuke Kosumi^{1

2}, Kosuke Mima^{1

2}, Hideo Baba², Shuji Ogino^{1

3

4

5}

¹ Department of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
² Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan.
³ Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
⁴ Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
⁵ Broad Institute of MIT and Harvard, Cambridge, MA, USA.

No abstract available

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

A Simple and Novel Fecal Biomarker for Colorectal Cancer: Ratio of Fusobacterium Nucleatum to Probiotics Populations, Based on Their Antagonistic Effect.
Guo S, Li L, Xu B, Li M, Zeng Q, Xiao H, Xue Y, Wu Y, Wang Y, Liu W, Zhang G. Guo S, et al. Clin Chem. 2018 Sep;64(9):1327-1337. doi: 10.1373/clinchem.2018.289728. Epub 2018 Jun 18. Clin Chem. 2018. PMID: 29914865

1. Routy B, Gopalakrishnan V, Daillere R, et al. The gut microbiota influences anticancer immunosurveillance and general health. Nat Rev Clin Oncol 2018;15:382–96. - PubMed
1. Brennan CA, Garrett WS. Gut Microbiota, Inflammation, and Colorectal Cancer. Annu Rev Microbiol 2016;70:395–411. - PMC - PubMed
1. Bullman S, Pedamallu CS, Sicinska E, et al. Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer. Science 2017;358:1443–8. - PMC - PubMed
1. Gopalakrishnan V, Helmink BA, Spencer CN, et al. The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy. Cancer Cell 2018;33:570–80. - PMC - PubMed
1. Gopalakrishnan V, Spencer CN, Nezi L, et al. Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients. Science 2018;359:97–103. - PMC - PubMed