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. 2018 Oct 22;18(1):199.
doi: 10.1186/s12872-018-0935-9.

Association between the intima-media thickness of the extracranial carotid arteries and metabolic syndrome in ethnic Kyrgyzs

Alina S Kerimkulova  1 , Olga S Lunegova  2 , Aibek E Mirrakhimov  3 , Saamay S Abilova  2 , Malik P Nabiev  2 , Ksenia V Neronova  2 , Erkaiym E Bektasheva  2 , Ulan M Toktomamatov  2 , Jyldyz E Esenbekova  2 , Erkin M Mirrakhimov  2   4
Affiliations

Association between the intima-media thickness of the extracranial carotid arteries and metabolic syndrome in ethnic Kyrgyzs

Alina S Kerimkulova et al. BMC Cardiovasc Disord. .

Abstract

Background: It is known that atherosclerosis is the leading cause of cardiovascular disease. We aimed to study the correlation between components of metabolic syndrome (MS) and subclinical carotid atherosclerosis in a group of ethnic Kyrgyzs.

Methods: In а descriptive study we assessed 144 ethnic Kyrgyzs (69 males, 75 females) aged 36-73 years (average age 51.03 ± 8.2). All participants underwent a clinical investigation and an anthropometric evaluation (weight, height, waist circumference (WC)). Abdominal obesity (АО) was confirmed at WC ≥ 94 cm in males and ≥ 88 cm in females. Fasting plasma glucose and lipid spectrum tests were performed. An ultrasound assessment of carotid intima-media thickness (IMT) was performed using a 7.5 MHz transducer (Phillips-SD 800).

Results: MS was revealed in 61 (42.4%; 47.8% in men and 37.3% in women) of the investigated patients. IMT was significantly increased with the presence of MS components in males (no components vs 2 components of MS: 0.67 ± 0.007 and 0.81 ± 0.009 respectively; р < 0.05) and females (no components vs 3 components of MS: 0.63 ± 0.007 and 0.76 ± 0.01 respectively; р < 0.01). IMT trended towards an increase in the presence of a greater number of MS components in patients with and without AO (р < 0.01). In order to identify independent factors affecting IMT we carried out a multifactorial logistic regression analysis. Arterial hypertension was found to have the greatest influence on the development of MS (OR = 3.81, p < 0.0001).

Conclusion: In the group of ethnic Kyrgyzs, a greater number of MS components, with AO or without AO, is associated with higher carotid IMT.

Keywords: Carotid arteries; Carotid atherosclerosis; Intima-media; Kyrgyz; Metabolic syndrome.

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Conflict of interest statement

Ethics approval and consent to participate

The study protocol was approved by the Ethical Committee of the Kyrgyz State Medical Academy named after I.K. Akhunbaev and was conducted in accordance with the Declaration of Helsinki. All patients who participated in this study provided written informed consent.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
The flow chart of the study
Fig. 2
Fig. 2
IMT in the carotid artery depending on the presence or absence of abdominal obesity. Notes: IMT - intima-media complex thickness; AO - abdominal obesity; MS - metabolic syndrome; the data are presented as mean ± standard deviation; * p < 0.01
See this image and copyright information in PMC

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