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Comment
. 2018 Nov;94(5):849-851.
doi: 10.1016/j.kint.2018.07.012.

HIF-1α drives cyst growth in advanced stages of autosomal dominant polycystic kidney disease

Alexis Hofherr  1 , Tilman Busch  1 , Michael Köttgen  2
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HIF-1α drives cyst growth in advanced stages of autosomal dominant polycystic kidney disease

Alexis Hofherr et al. Kidney Int. 2018 Nov.
Free article

Abstract

Progressive cyst expansion in autosomal-dominant polycystic kidney disease has been shown to cause regional hypoxia in cystic and pericystic tissue. This results in up-regulation of hypoxia-inducible transcription factor (HIF) 1α in cyst epithelial cells. However, the functional impact of HIF-1α in cystic kidney disease was unknown. A new study has shown that HIF-1α promotes cyst progression in a mouse model of autosomal-dominant polycystic kidney disease.

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