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. 2018 Nov-Dec;32(6):1519-1525.
doi: 10.21873/invivo.11409.

Spleen Dose-Volume Parameters as a Predictor of Treatment-related Lymphopenia During Definitive Chemoradiotherapy for Esophageal Cancer

Tetsuo Saito  1 , Ryo Toya  2 , Naoya Yoshida  3 , Takashi Shono  4 , Tomohiko Matsuyama  2 , Satoshi Ninomura  2 , Takahiro Watakabe  2 , Yutaka Sasaki  4 , Hideo Baba  3 , Natsuo Oya  2
Affiliations

Spleen Dose-Volume Parameters as a Predictor of Treatment-related Lymphopenia During Definitive Chemoradiotherapy for Esophageal Cancer

Tetsuo Saito et al. In Vivo. 2018 Nov-Dec.

Abstract

Aim: Our study sought to identify dosimetric predictors of treatment-related lymphopenia during chemoradiotherapy for esophageal cancer.

Materials and methods: Patients with esophageal cancer who had received definitive chemoradiotherapy at our Institution were retrospectively assessed. The absolute volume of the spleen, body, and bone marrow that had received 5, 10, 20, and 30 Gy and the mean splenic dose were recorded.

Results: Multivariate linear regression analysis revealed that docetaxel use and spleen dose-volume parameters (V5, V10, V20, V30, and mean splenic dose) were significant independent factors negatively influencing the absolute lymphocyte count at nadir. An increase of 1 Gy in mean splenic dose predicted a 2.9% decrease in nadir absolute lymphocyte count. Univariable logistic regression analysis showed that the mean splenic dose was a significant predictor of grade 4 lymphopenia. None of the body or bone marrow dose-volume parameters significantly predicted lymphopenia.

Conclusion: Higher spleen dose-volume parameters were associated with severe lymphopenia during chemoradiotherapy.

Keywords: Treatment-related lymphopenia; bone marrow; chemoradiotherapy; dose–volume parameters; spleen.

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Figures

Figure 1
Figure 1. Spearman correlation coefficients (r) were used to evaluate associations between spleen dose–volume parameters and absolute lymphocytecount (ALC) at nadir.
See this image and copyright information in PMC

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