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Review
. 2018 Oct 16:13:1177271918806840.
doi: 10.1177/1177271918806840. eCollection 2018.

MicroRNAs as Biomarkers of B-cell Lymphoma

Carla Solé  1 , Esther Arnaiz  1 , Charles H Lawrie  1   2   3
Affiliations
Review

MicroRNAs as Biomarkers of B-cell Lymphoma

Carla Solé et al. Biomark Insights. .

Abstract

B-cell lymphomas represent a diverse group of neoplasms classified primarily by histopatholgy and are often challenging to accurately diagnose. Despite having been recognized less than 20 years ago, microRNAs (miRNAs) have emerged as one of the most promising class of cancer molecular biomarkers and are particularly attractive as they can be readily detected in formalin-fixed paraffin-embedded biopsy material and biological fluids such as blood. Many of the identified B-cell lymphoma miRNA biomarkers also play crucial regulatory roles in normal B-cell development. Below we consider the identity, function, and biomarker potential of miRNAs in B-cell lymphoma and most importantly the barriers that remain to be overcome if they are really to become part of routine clinical practice.

Keywords: B-cell lymphoma; Hodgkin lymphoma; biomarker; liquid biopsies; microRNA; non-Hodgkin lymphoma.

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Conflict of interest statement

Declaration of conflicting interests:The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Schematic diagram of the major B-cell lymphoma miRNA biomarkers that have been identified and their relationship to B-cell development. BL indicates Burkitt lymphoma; CLL, chronic lymphocytic leukaemia; DLBCL, diffuse large B-cell lymphoma; FL, follicular lymphoma; HL, Hodgkin lymphoma; miRNA, microRNA; MALT, mucosa-associated lymphoid tissue; MCL, mantle cell lymphoma; PBMCs, peripheral blood mononuclear cells; SMZL, splenic marginal zone lymphoma.
See this image and copyright information in PMC

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