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. 2018 Dec;7(4):269-278.
doi: 10.1007/s40204-018-0101-6. Epub 2018 Oct 22.

Polyurethane synthesis for vascular application

Zahra Zaredar  1 , Fahimeh Askari  2 , Parvin Shokrolahi  3
Affiliations

Polyurethane synthesis for vascular application

Zahra Zaredar et al. Prog Biomater. 2018 Dec.

Abstract

Three polyurethane formulations were prepared on the basis of siloxane; two formulations contained 1% and 3% of a hydroxyl functionalized polyhedral oligomeric silsesquioxane [POSS (ROH)2] nano-particles (as a co-chain extender) and one was without nano-particle. Structures of the polyurethanes were characterized by FTIR and SEM. The effect of POSS nano-particles on properties of the synthesized PUs was examined for vascular applications by tensile test, contact angle, SEM, AFM and endothelial cells viability evaluation. Properties of the polyurethane with 1% POSS were compared with those of PU without POSS and the results showed 66% increase in the elongation-at-break, 53% increase in tensile strength and 33% increase in modulus, 9.45% increase in contact angle, 76.7% reduction in surface roughness and 9.46% increase in cell viability. It was also shown that a polyurethane containing 1% of POSS nano-particles in its structure developed the highest hydrophobicity, which resulted in its lowest potential for thrombosis.

Keywords: Biocompatibility; POSS nano-particles; Polyurethane; Siloxane macrodiol; Vascular applications.

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Conflict of interest statement

Conflict of interest

F. Askari declares that she has no conflict of interest. Z. Zaredar declares that he has no conflict of interest. P. Shokrolahi declares that she has no conflict of interest.

Research involving human and/or animals

This article does not contain any studies with human participants or animals performed by any of the authors.

Figures

Fig. 1
Fig. 1
Synthesis route of PU-BDO
Fig. 2
Fig. 2
Synthesis route of PU-BDO/POSS
Fig. 3
Fig. 3
ATR-FTIR spectra of the PUs
Fig. 4
Fig. 4
SEM images taken at the PUs’ fracture surface; a distribution of nano-particles in PU-BDO, b distribution of nano-particles in PU-BDO/POSS 1, and c distribution of nano-particles in PU-BDO/POSS 3
Fig. 5
Fig. 5
Stress–stress curves of the synthesized PU-BDO, PU-BDO/POSS 1, and PU-BDO/POSS 3
Fig. 6
Fig. 6
AFM images of the synthesized polyurethanes; a PU-BDO, b PU-BDO/POSS1, and c PU-BDO3
Fig. 7
Fig. 7
Cell viability evaluation result as measured by MTT assay. Standard deviations are less than 0.025 for all the samples
See this image and copyright information in PMC

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