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. 2019 Jan;49(1):349-362.
doi: 10.1007/s10803-018-3767-7.

Development of a Brief Parent-Report Screen for Common Gastrointestinal Disorders in Autism Spectrum Disorder

Kara G Margolis  1 , Timothy M Buie  2 , J Blake Turner  3 , Anna E Silberman  3 , Judith F Feldman  3 , Katherine F Murray  2 , Maureen McSwiggan-Hardin  3 , Joseph Levy  4 , Margaret L Bauman  5 , Jeremy Veenstra-VanderWeele  3 , Agnes H Whitaker  3 , Harland S Winter  2
Affiliations

Development of a Brief Parent-Report Screen for Common Gastrointestinal Disorders in Autism Spectrum Disorder

Kara G Margolis et al. J Autism Dev Disord. 2019 Jan.

Abstract

Gastrointestinal dysfunction in children with autism spectrum disorder (ASD) is common and associated with problem behaviors. This study describes the development of a brief, parent-report screen that relies minimally upon the child's ability to report or localize pain for identifying children with ASD at risk for one of three common gastrointestinal disorders (functional constipation, functional diarrhea, and gastroesophageal reflux disease). In a clinical sample of children with ASD, this 17-item screen identified children having one or more of these disorders with a sensitivity of 84%, specificity of 43%, and a positive predictive value of 67%. If found to be valid in an independent sample of children with ASD, the screen will be useful in both clinical practice and research.

Keywords: Autism; Behavior; Comorbidities; GI; Gastrointestinal; Screen.

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Conflict of interest statement

Compliance with Ethical Standards

Potential conflicts of interest: All authors declare no conflicts of interest

Figures

Fig. 1.
Fig. 1.
Item Characteristic Curves and Discriminations for the Four ATN GI Symptoms Inventory Dimensions
Fig. 1.
Fig. 1.
Item Characteristic Curves and Discriminations for the Four ATN GI Symptoms Inventory Dimensions
Fig. 1.
Fig. 1.
Item Characteristic Curves and Discriminations for the Four ATN GI Symptoms Inventory Dimensions
Fig. 1.
Fig. 1.
Item Characteristic Curves and Discriminations for the Four ATN GI Symptoms Inventory Dimensions
See this image and copyright information in PMC

References

    1. (2005). Autism Treatment Network, GI symptom inventory questionnaire, vers. 3.0. New York, NY, Autism Speaks.
    1. Alabaf S, Gillberg C, Lundstrom S, Lichtenstein P, Kerekes N, Rastam M and Anckarsater H (2018). “Physical health in children with neurodevelopmental disorders.” J Autism Dev Disord. - PMC - PubMed
    1. Baran M, Cagan Appak Y, Karakoyun M, Yalcinkaya S, Eliacik K and Dundar BN (2017). “The overlap of gastroesophageal reflux disease and functional constipation in children: the efficacy of constipation treatment.” Eur J Gastroenterol Hepatol 29(11): 1264–1268. - PubMed
    1. Bauman ML (2010). “Medical comorbidities in autism: challenges to diagnosis and treatment.” Neurotherapeutics 7(3): 320–327. - PMC - PubMed
    1. Buie T, Campbell DB, Fuchs GJ 3rd, Furuta GT, Levy J, Vandewater J, Whitaker AH, Atkins D, Bauman ML, Beaudet AL, Carr EG, Gershon MD, Hyman SL, Jirapinyo P, Jyonouchi H, Kooros K, Kushak R, Levitt P, Levy SE, Lewis JD, Murray KF, Natowicz MR, Sabra A, Wershil BK, Weston SC, Zeltzer L and Winter H (2010). “Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report.” Pediatrics 125 Suppl 1: S1–18. - PubMed