An Introduction to Drug Testing: The Expanding Role of Mass Spectrometry

Abstract

Measurement of drugs and their metabolites in biological fluids is the foundation of both therapeutic drug monitoring (TDM) and toxicology. The introduction of methods based on mass spectrometry (MS), coupled with gas or liquid chromatography, has revolutionized these areas. This chapter will introduce the reader to the application of MS to TDM and toxicology, the steps that should be considered during implementation and the processes that should be implemented to assure continued quality. Points of emphasis include advances and recent trends since the publication of the first edition of this book, such as high-resolution mass spectrometry and increased interest in alternate matrices.

Keywords: Drug testing; Gas chromatography; Liquid chromatography; Mass spectrometry; Therapeutic drug monitoring; Toxicology.