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Comment
. 2018 Oct 23:7:e42291.
doi: 10.7554/eLife.42291.

The central role of serotonin

Affiliations
Comment

The central role of serotonin

Gary C Mouradian et al. Elife. .

Abstract

The neurotransmitter serotonin helps to co-ordinate the respiratory and cardiovascular responses of newborns to oxygen deprivation.

Keywords: SIDS; autoresuscitation; chemogenetics; human biology; medicine; mouse; neonatal; neuroscience; raphe; serotonergic system.

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Conflict of interest statement

GM, MH No competing interests declared

Comment on

References

    1. Barrett KT, Dosumu-Johnson RT, Daubenspeck JA, Brust RD, Kreouzis V, Kim JC, Li A, Dymecki SM, Nattie EE. Partial raphe dysfunction in neurotransmission is sufficient to increase mortality after anoxic exposures in mice at a critical period in postnatal development. Journal of Neuroscience. 2016;36:3943–3953. doi: 10.1523/JNEUROSCI.1796-15.2016. - DOI - PMC - PubMed
    1. Cummings KJ, Commons KG, Fan KC, Li A, Nattie EE. Severe spontaneous bradycardia associated with respiratory disruptions in rat pups with fewer brain stem 5-HT neurons. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 2009;296:R1783–R1796. doi: 10.1152/ajpregu.00122.2009. - DOI - PMC - PubMed
    1. Cummings KJ, Commons KG, Hewitt JC, Daubenspeck JA, Li A, Kinney HC, Nattie EE. Failed heart rate recovery at a critical age in 5-HT-deficient mice exposed to episodic anoxia: implications for SIDS. Journal of Applied Physiology. 2011;111:825–833. doi: 10.1152/japplphysiol.00336.2011. - DOI - PMC - PubMed
    1. Dosumu-Johnson RT, Cocoran AE, Chang Y, Nattie E, Dymecki AM. Acute perturbation of Pet1-neuron activity in neonatal mice impairs cardiorespiratory homeostatic recovery. eLife. 2018;7:e37857. doi: 10.7554/eLife.37857. - DOI - PMC - PubMed
    1. Duncan JR, Paterson DS, Hoffman JM, Mokler DJ, Borenstein NS, Belliveau RA, Krous HF, Haas EA, Stanley C, Nattie EE, Trachtenberg FL, Kinney HC. Brainstem serotonergic deficiency in sudden infant death syndrome. JAMA. 2010;303:430–437. doi: 10.1001/jama.2010.45. - DOI - PMC - PubMed