Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Mar 26;400(4):457-466.
doi: 10.1515/hsz-2018-0368.

The structural biology of the shelterin complex

Yong Chen  1   2
Affiliations
Free article
Review

The structural biology of the shelterin complex

Yong Chen. Biol Chem. .
Free article

Abstract

The shelterin complex protects telomeric DNA and plays critical roles in maintaining chromosome stability. The structures and functions of the shelterin complex have been extensively explored in the past decades. This review summarizes the current progress on structural studies of shelterin complexes from different species. It focuses on the structural features and assembly of common structural domains, highlighting the evolutionary plasticity and conserved roles of shelterin proteins in telomere homeostasis and protection.

Keywords: DNA binding; protein-protein interaction; shelterin complex; structural biology; telomere; telomeric protein.

PubMed Disclaimer

References

    1. Azad, G.K. and Tomar, R.S. (2016). The multifunctional transcription factor Rap1: a regulator of yeast physiology. Front Biosci. 21, 918–930.
    1. Baumann, P. and Cech, T.R. (2001). Pot1, the putative telomere end-binding protein in fission yeast and humans. Science 292, 1171–1175.
    1. Benarroch-Popivker, D., Pisano, S., Mendez-Bermudez, A., Lototska, L., Kaur, P., Bauwens, S., Djerbi, N., Latrick, C.M., Fraisier, V., Pei, B., et al. (2016). TRF2-mediated control of telomere DNA topology as a mechanism for chromosome-end protection. Mol. Cell 61, 274–286.
    1. Bianchi, A., Stansel, R.M., Fairall, L., Griffith, J.D., Rhodes, D., and de Lange, T. (1999). TRF1 binds a bipartite telomeric site with extreme spatial flexibility. EMBO J. 18, 5735–5744.
    1. Broccoli, D., Smogorzewska, A., Chong, L., and de Lange, T. (1997). Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat. Genet. 17, 231–235.

Publication types

LinkOut - more resources