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. 1987 Jul;61(7):2311-5.
doi: 10.1128/JVI.61.7.2311-2315.1987.

Nerve growth factor deprivation results in the reactivation of latent herpes simplex virus in vitro

C L Wilcox, E M Johnson Jr

Nerve growth factor deprivation results in the reactivation of latent herpes simplex virus in vitro

C L Wilcox et al. J Virol. 1987 Jul.

Abstract

Primary sympathetic neuronal cultures were maintained for up to 5 weeks after inoculation with herpes simplex virus (HSV) without evidence of viral infection. Upon deprivation of nerve growth factor, the cultures produced infectious HSV, indicating that the cultures harbored latent HSV. This study demonstrates a function of nerve growth factor in the maintenance of HSV latency.

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References

    1. J Virol. 1968 Jun;2(6):621-8 - PubMed
    1. Proc Natl Acad Sci U S A. 1969 Oct;64(2):787-94 - PubMed
    1. Exp Cell Res. 1970 Mar;59(3):383-92 - PubMed
    1. J Gen Virol. 1972 Feb;14(2):189-97 - PubMed
    1. Science. 1972 Oct 20;178(4058):306-7 - PubMed

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