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Meta-Analysis
. 2018 Oct 23;18(1):274.
doi: 10.1186/s12886-018-0945-5.

Association between genetic variation of complement C3 and the susceptibility to advanced age-related macular degeneration: a meta-analysis

Jun Zhang  1 , Shuang Li  1 , Shuqiong Hu  2 , Jiguo Yu  1 , Yi Xiang  3
Affiliations
Meta-Analysis

Association between genetic variation of complement C3 and the susceptibility to advanced age-related macular degeneration: a meta-analysis

Jun Zhang et al. BMC Ophthalmol. .

Abstract

Background: The purpose of this study is to discuss whether genetic variants (rs2230199, rs1047286, rs2230205, and rs2250656) in the C3 gene account for a significant risk of advanced AMD.

Methods: We performed a meta-analysis using electronic databases to search relevant articles. A total of 40 case-control studies from 38 available articles (20,673 cases and 20,025 controls) were included in our study.

Results: In our meta-analysis, the pooled results showed that the carriage of G allele for rs2230199 and the T allele for rs1047286 had a tendency to the risk of advanced AMD (OR = 1.49, 95% CI = 1.39-1.59, P < 0.001; OR = 1.45, 95% CI = 1.37-1.54, P < 0.001). Moreover, in the subgroup analysis based on ethnicity, rs2230199 and rs1047286 polymorphisms were more likely to be a predictor of response for Caucasian region (OR = 1.48, 95% CI = 1.38-1.59, P < 0.001; OR = 1.45, 95% CI = 1.37-1.54, P < 0.001). Besides, pooled results suggested that the G allele of rs2230199 could confer susceptibility to advanced AMD in Middle East (OR = 1.62, 95% CI = 1.33-1.97, P < 0.001).

Conclusion: In our meta-analysis, C3 genetic polymorphisms unveiled a positive effect on the risk of advanced AMD, especially in Caucasians. Furthermore, numerous well-designed studies with large sample-size are required to validate this conclusion.

Keywords: Age-related macular degeneration; C3 gene; Meta-analysis; Polymorphism.

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The authors declare that they have no competing interests.

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Figures

Fig. 1
Fig. 1
Flow diagram presenting the result of literature searching process in meta-analysis
Fig. 2
Fig. 2
Evaluation of the association between C3 genetic polymorphism (rs2230199) with advanced AMD
Fig. 3
Fig. 3
Assessment of the association between C3 genetic polymorphism (rs1047286) with advanced AMD
Fig. 4
Fig. 4
Estimation of the association between C3 genetic polymorphism (rs2230205) with advanced AMD
Fig. 5
Fig. 5
Evaluation of the association between C3 genetic polymorphism (rs225065) with advanced AMD
Fig. 6
Fig. 6
Evaluation of the sensitivity analysis between C3 genetic polymorphism (rs2230199) with advanced AMD
See this image and copyright information in PMC

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