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Review
. 2019 Apr;37(4):389-401.
doi: 10.1016/j.tibtech.2018.09.010. Epub 2018 Oct 21.

Safe CRISPR: Challenges and Possible Solutions

Michael Pineda  1 , Ashley Lear  1 , James P Collins  2 , Samira Kiani  3
Affiliations
Review

Safe CRISPR: Challenges and Possible Solutions

Michael Pineda et al. Trends Biotechnol. 2019 Apr.

Abstract

Applications of CRISPR in human health and in gene drives are at the forefront of biological research as tools. This technology will affect humankind and our environment, so as this technology pushes forward, the design and implementation of safety measures is imperative. Novel technologies and forethought in various applications of CRISPR are essential for using this technology safely. Here, we review environmental and health-related safety concerns associated with using CRISPR and ways proposed to minimize risk.

Keywords: CRISPR; biosafety; gene drives; gene therapies.

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