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. 1987 Feb;37(1):28-32.

Observations on the replication of ectromelia virus in mouse-derived cell lines: implications for epidemiology of mousepox

R M Buller, A C Weinblatt, A W Hamburger, G D Wallace
  • PMID: 3035276

Observations on the replication of ectromelia virus in mouse-derived cell lines: implications for epidemiology of mousepox

R M Buller et al. Lab Anim Sci. 1987 Feb.

Abstract

Ectromelia virus was shown to replicate in vitro in all lymphoma cell lines and in a small proportion of hybridoma lines tested. It was demonstrated that certain hybridoma cell lines, which were passed in ectromelia virus-infected mice, yielded ectromelia virus infectivity on explantation into tissue culture. This finding further substantiated the belief that ascitic fluid and hybridoma cell lines exposed to virus during mouse-passage could be important in the epidemiology of mousepox.

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