doi: 10.1016/0022-4731(87)90103-8.
The cholecalciferol sulphate system in mammals
- PMID: 3035283
- DOI: 10.1016/0022-4731(87)90103-8
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The cholecalciferol sulphate system in mammals
J Steroid Biochem.
1987 Mar.
Abstract
7-Dehydrocholesterol sulphate has been identified in human and rat skin. The compound was isolated by anion exchange chromatography and following hydrolysis it was characterized by high-performance liquid chromatography and gas chromatography-mass spectrometry. Experiments with rats showed that 7-dehydrocholesterol sulphate can serve as a precursor of cholecalciferol sulphate and 25-hydroxy-cholecalciferol 3-sulphate, the latter compound being present in significant amounts in human blood. The sulphated sterols identified represent a previously unknown secosteroid system in mammals.