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Comment
. 2018 Dec;8(12):1498.
doi: 10.1158/2159-8290.CD-NB2018-131. Epub 2018 Oct 23.

NK Cells Respond to Checkpoint Blockade

No authors listed
Comment

NK Cells Respond to Checkpoint Blockade

No authors listed. Cancer Discov. 2018 Dec.

Abstract

A recent study suggests that natural killer (NK) cells may play an important role in antitumor response to immune checkpoint inhibitors. Researchers used mouse models to show that NK cells respond to PD-1 and PD-L1 inhibitors, information that could be used to develop immunotherapies that tap NK cells to combat cancer.

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  • Contribution of NK cells to immunotherapy mediated by PD-1/PD-L1 blockade.
    Hsu J, Hodgins JJ, Marathe M, Nicolai CJ, Bourgeois-Daigneault MC, Trevino TN, Azimi CS, Scheer AK, Randolph HE, Thompson TW, Zhang L, Iannello A, Mathur N, Jardine KE, Kirn GA, Bell JC, McBurney MW, Raulet DH, Ardolino M. Hsu J, et al. J Clin Invest. 2018 Oct 1;128(10):4654-4668. doi: 10.1172/JCI99317. Epub 2018 Sep 10. J Clin Invest. 2018. PMID: 30198904 Free PMC article.

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