A call to arms: Unifying the fight against resistance

Alexis Kaushansky^{1

2}, Lizbeth Hedstrom³, Aaron Goldman^{4

5}, Juswinder Singh⁶, Priscilla L Yang⁷, Pradipsinh K Rathod⁸, Michael Cynamon⁹, Dominik Wodarz¹⁰, Daruka Mahadevan¹¹, Andrew Tomaras¹², Manuel A Navia¹³, Celia A Schiffer^{14

15}

Affiliations

¹ Department of Global Health, University of Washington, Seattle, WA 98109, USA. alexis.kaushansky@seattlechildrens.org.
² Center for Infectious Disease Research, Seattle, WA 98109, USA.
³ Departments of Biology and Chemistry, Brandeis University, Waltham, MA 02453, USA.
⁴ Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
⁵ Division of Biomedical Engineering, Brigham and Women's Hospital, Boston, MA 02115, USA.
⁶ Ankaa Therapeutics LLC, Southborough, MA 01772, USA.
⁷ Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.
⁸ Department of Chemistry, University of Washington, Seattle, WA 98195, USA.
⁹ Department of Medicine, Veterans Affairs Medical Center, Syracuse, NY 13210, USA.
¹⁰ Department of Ecology and Evolutionary Biology, University of California, Irvine, Irvine, CA 92697, USA.
¹¹ Department of Medicine, University of Arizona, Tucson, AZ 85724, USA.
¹² BacterioScan Inc., St. Louis, MO 63108, USA.
¹³ Hub-Bio Strategic Advising, Lexington, MA 02420, USA.
¹⁴ Institute of Drug Resistance, Worcester, MA 01605, USA.
¹⁵ Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

PMID: 30352947
PMCID: PMC6464114
DOI: 10.1126/scisignal.aav0442

Editorial

A call to arms: Unifying the fight against resistance

Alexis Kaushansky et al. Sci Signal. 2018.

. 2018 Oct 23;11(553):eaav0442.

doi: 10.1126/scisignal.aav0442.

Authors

Affiliations

¹ Department of Global Health, University of Washington, Seattle, WA 98109, USA. alexis.kaushansky@seattlechildrens.org.
² Center for Infectious Disease Research, Seattle, WA 98109, USA.
³ Departments of Biology and Chemistry, Brandeis University, Waltham, MA 02453, USA.
⁴ Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
⁵ Division of Biomedical Engineering, Brigham and Women's Hospital, Boston, MA 02115, USA.
⁶ Ankaa Therapeutics LLC, Southborough, MA 01772, USA.
⁷ Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.
⁸ Department of Chemistry, University of Washington, Seattle, WA 98195, USA.
⁹ Department of Medicine, Veterans Affairs Medical Center, Syracuse, NY 13210, USA.
¹⁰ Department of Ecology and Evolutionary Biology, University of California, Irvine, Irvine, CA 92697, USA.
¹¹ Department of Medicine, University of Arizona, Tucson, AZ 85724, USA.
¹² BacterioScan Inc., St. Louis, MO 63108, USA.
¹³ Hub-Bio Strategic Advising, Lexington, MA 02420, USA.
¹⁴ Institute of Drug Resistance, Worcester, MA 01605, USA.
¹⁵ Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

PMID: 30352947
PMCID: PMC6464114
DOI: 10.1126/scisignal.aav0442

Abstract

This Editorial discusses the state of research on drug resistance in the fields of cancer, infectious disease, and agriculture. Reaching across the aisle for a more cross-collaborative approach may lead to exciting breakthroughs toward tackling the challenges of drug resistance in each field.

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References

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1. Goldman A et al., Rationally Designed 2-in-1 Nanoparticles Can Overcome Adaptive Resistance in Cancer. ACS Nano 10, 5823–5834 (2016). - PubMed
1. Slager J, Kjos M, Attaiech L, Veening JW, Antibiotic-induced replication stress triggers bacterial competence by increasing gene dosage near the origin. Cell 157, 395–406 (2014). - PubMed
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1. Gupta PB et al., Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell 146, 633–644 (2011). - PubMed

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A call to arms: Unifying the fight against resistance

Affiliations

A call to arms: Unifying the fight against resistance

Authors

Affiliations

Abstract

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Miscellaneous