doi: 10.1016/0304-3940(87)90430-7.
GABAergic nerve terminals in rat hippocampus possess alpha 2-adrenoceptors regulating GABA release
- PMID: 3035440
- DOI: 10.1016/0304-3940(87)90430-7
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GABAergic nerve terminals in rat hippocampus possess alpha 2-adrenoceptors regulating GABA release
Neurosci Lett.
.
Abstract
Noradrenaline enhanced in a concentration-dependent way the basal release of endogenous GABA from superfused rat hippocampus synaptosomes. The alpha 2-adrenoceptor antagonist yohimbine prevented the releasing effect of noradrenaline while the alpha 1-adrenoceptor antagonist prazosin was ineffective. It is concluded that GABAergic nerve terminals in rat hippocampus possess adrenoceptors of the alpha 2-subtype whose activation causes enhancement of GABA release.
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