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. 1987 May 19;76(3):363-7.
doi: 10.1016/0304-3940(87)90430-7.

GABAergic nerve terminals in rat hippocampus possess alpha 2-adrenoceptors regulating GABA release

A Pittaluga, M Raiteri

GABAergic nerve terminals in rat hippocampus possess alpha 2-adrenoceptors regulating GABA release

A Pittaluga et al. Neurosci Lett. .

Abstract

Noradrenaline enhanced in a concentration-dependent way the basal release of endogenous GABA from superfused rat hippocampus synaptosomes. The alpha 2-adrenoceptor antagonist yohimbine prevented the releasing effect of noradrenaline while the alpha 1-adrenoceptor antagonist prazosin was ineffective. It is concluded that GABAergic nerve terminals in rat hippocampus possess adrenoceptors of the alpha 2-subtype whose activation causes enhancement of GABA release.

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