Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2018 Oct;11(10):e008298.
doi: 10.1161/CIRCIMAGING.118.008298.

Imaging the Microstructure of the Human Fetal Heart

David E Sosnovik  1 , Tal Geva  2
Affiliations
Editorial

Imaging the Microstructure of the Human Fetal Heart

David E Sosnovik et al. Circ Cardiovasc Imaging. 2018 Oct.
No abstract available

Keywords: Editorial; diffusion tensor imaging; heart; heart defects, congenital; magnetic resonance imaging; myocardium.

PubMed Disclaimer

Figures

Figure 1:
Figure 1:. DTI-Tractography of fiber architecture in human fetal and adult hearts.
(A-D) The development of helical myofiber tracts in the human fetal heart occurs gradually in the second trimester. (E) Adult human heart showing a fully matured myofiber pattern, in which subendocardial and subepicardial fibers cross over each other with an angle of approximately 120°. (F-H) The propagation angle or curvature of myofiber tracts in the human heart is highly uniform. Reproduced with permission from Mekkaoui et al., , PN = postnatal.
See this image and copyright information in PMC

Comment on

References

    1. Streeter DD Jr., Spotnitz HM, Patel DP, Ross J Jr. and Sonnenblick EH. Fiber orientation in the canine left ventricle during diastole and systole. Circ Res. 1969;24:339–47. - PubMed
    1. Sosnovik DE, Mekkaoui C, Huang S, Chen HH, Dai G, Stoeck CT, Ngoy S, Guan J, Wang R, Kostis WJ, Jackowski MP, Wedeen VJ, Kozerke S and Liao R. Microstructural impact of ischemia and bone marrow-derived cell therapy revealed with diffusion tensor magnetic resonance imaging tractography of the heart in vivo. Circulation. 2014;129:1731–41. - PMC - PubMed
    1. Mekkaoui C, Reese TG, Jackowski MP, Cauley SF, Setsompop K, Bhat H and Sosnovik DE. Diffusion Tractography of the Entire Left Ventricle by Using Free-breathing Accelerated Simultaneous Multisection Imaging. Radiology. 2017;282:850–856. - PMC - PubMed
    1. Dou J, Tseng WY, Reese TG and Wedeen VJ. Combined diffusion and strain MRI reveals structure and function of human myocardial laminar sheets in vivo. Magn Reson Med. 2003;50:107–13. - PubMed
    1. Perotti LE, Magrath P, Verzhbinsky IA, Aliotta E, Moulin K and Ennis DB. Microstructurally Anchored Cardiac Kinematics by Combining In Vivo DENSE MRI and cDTI. Funct Imaging Model Heart. 2017;10263:381–391. - PMC - PubMed