Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2018 Aug 17;123(5):512-514.
doi: 10.1161/CIRCRESAHA.118.313472.

Strategies for Improving the Maturity of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Chengyi Tu  1 , Benjamin S Chao  1 , Joseph C Wu  1   2   3
Affiliations
Editorial

Strategies for Improving the Maturity of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Chengyi Tu et al. Circ Res. .
No abstract available

Keywords: Editorials; NF-kappa B; adult; humans; myocytes, cardiac.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Schematic illustration of existing in vitro maturation strategies for stem cell-derived CMs. Biophysical methods (upper panel) include electrical stimulations (e.g., field stimulation and biowire), mechanical stretch (e.g., cyclic stretch and static stretch), and substrate modulation (e.g., stiffness and ligands). Biochemical methods (lower panel) include metabolic modulation (e.g., fatty acids and hormones), genetic manipulation (e.g., miRNA overexpression), and co-culture with other cell types (e.g., fibroblasts and endothelial cells).
See this image and copyright information in PMC

References

    1. Lan F, Lee AS, Liang P, et al. Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells. Cell Stem Cell 2013;12:101–13. - PMC - PubMed
    1. Liang P, Sallam K, Wu H, et al. Patient-specific and genome-edited induced pluripotent stem cell-derived cardiomyocytes elucidate single cell phenotype of Brugada Syndrome. Journal American College of Cardiology 2016;68(19):2086–2096. - PMC - PubMed
    1. Liu C, Oikonomopoulos A, Sayed N and Wu JC. Modeling human diseases with induced pluripotent stem cells: from 2D to 3D and beyond. Development 2018;145. - PMC - PubMed
    1. Burridge PW, Li YF, Matsa E, et al. Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity. Nat Med 2016;22:547–56. - PMC - PubMed
    1. Sharma A, Burridge PW, McKeithan WL, et al. High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells. Sci Transl Med 2017;9:eaaf2584. - PMC - PubMed

Publication types

MeSH terms