Molecular Pathogenesis of the Tauopathies

Abstract

The tauopathies constitute a group of diseases that have Tau inclusions in neurons or glia as their common denominator. In this review, we describe the biochemical and histological differences in Tau pathology that are characteristic of the spectrum of frontotemporal lobar degeneration as primary tauopathies and of Alzheimer's disease as a secondary tauopathy, as well as the commonalities and differences between the familial and sporadic forms. Furthermore, we discuss selected advances in transgenic animal models in delineating the different pathomechanisms of Tau.

Keywords: AD; Alzheimer's disease; FTLD; frontotemporal lobar degeneration; microtubule-associated protein Tau; neuropathology; signaling cascade; tauopathy.