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. 2018 Nov;49(11):2783-2785.
doi: 10.1161/STROKEAHA.118.022919.

Endovascular Thrombectomy

Yuefei Wu  1 , Congguo Yin  2 , Jianhong Yang  1 , Lin Jiang  2 , Mark W Parsons  3   4 , Longting Lin  4
Affiliations

Endovascular Thrombectomy

Yuefei Wu et al. Stroke. 2018 Nov.

Abstract

Background and Purpose- This study aimed to explore safety of tirofiban in endovascular treatment of acute ischemic stroke. Methods- Two hundred eighteen ischemic stroke patients receiving endovascular thrombectomy were prospectively recruited, with 94 treated with intra-arterial tirofiban and 124 were not. The 2 groups were compared in terms of symptomatic intracranial hemorrhage (ICH) and fatal ICH rate by the χ2 test and logistic regression. Results- Patients treated with tirofiban compared with those without tirofiban had significantly higher rate of symptomatic ICH (14.6% versus 5.7%; P=0.027) and fatal ICH (8.8% versus 1.6%; P=0.014). Tirofiban-treated patients had increased odds of symptomatic ICH by 2.9-fold (95% CI, 1.1-7.5), and odds of fatal ICH increased by 5.9-fold (95% CI, 1.2-28.4). Conclusions- Tirofiban treatment increases risk of major ICH after endovascular thrombectomy for acute ischemic stroke in this nonrandomized study.

Keywords: hemorrhage; intracranial hemorrhage; risk; stroke; thrombectomy.

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