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. 1987 Jun;84(11):3846-50.
doi: 10.1073/pnas.84.11.3846.

Genomic organization of the mouse T-cell receptor beta-chain gene family

E Lai, R K Barth, L Hood

Genomic organization of the mouse T-cell receptor beta-chain gene family

E Lai et al. Proc Natl Acad Sci U S A. 1987 Jun.

Abstract

We have combined three different methods, deletion mapping of T-cell lines, field-inversion gel electrophoresis, and the restriction mapping of a cosmid clone, to construct a physical map of the murine T-cell receptor beta-chain gene family. We have mapped 19 variable (V beta) gene segments and the two clusters of diversity (D beta) and joining (J beta) gene segments and constant (C beta) genes. These members of the beta-chain gene family span approximately equal to 450 kilobases of DNA, excluding one potential gap in the DNA fragment alignments.

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References

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