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Comparative Study
. 2018 Jan 23:7:100.
doi: 10.12688/f1000research.13732.1. eCollection 2018.

Comparative genomic analysis of crustacean hyperglycemic hormone (CHH) neuropeptide genes across diverse crustacean species

Wai Hoong Chang  1 , Alvina G Lai  1
Affiliations
Comparative Study

Comparative genomic analysis of crustacean hyperglycemic hormone (CHH) neuropeptide genes across diverse crustacean species

Wai Hoong Chang et al. F1000Res. .

Abstract

Background: Recent studies on bioactive peptides have shed light on the importance of these compounds in regulating a multitude of physiological, behavioral and biological processes in animals. Specifically, the neuropeptides of the crustacean hyperglycemic hormone (CHH) superfamily is known to control a number of important functions ranging from energy metabolism, molting, osmoregulation to reproduction. Methods: Given the importance of this peptide family, we employed a conservative approach utilizing extant transcriptome datasets from 112 crustacean species, which not only include important food crop species from the order Decapoda, but also from other lower order crustaceans (Branchiopoda and Copepoda), to identify putative CHH-like sequences. Results and conclusions: Here we describe 413 genes that represent a collection of CHH-like peptides in Crustacea, providing an important staging point that will now facilitate the next stages of neuroendocrine research across the wider community.

Keywords: Comparative genomics; Crustacean Hyperglycemic Hormone (CHH); Crustaceans; Neuropeptides; Transcriptomics.

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Conflict of interest statement

No competing interests were disclosed.

Figures

Figure 1.
Figure 1.. Phylogenetic relationship of Crustacea.
The number of species within each taxon is denoted in parentheses.
Figure 2.
Figure 2.. CHH/MIH/GIH genes in Crustacea.
Heat maps denote the number of CHH/MIH/GIH genes identified from each crustacean species. CHH/MIH/GIH genes from five non-crustacean species within Arthropoda are also shown.
Figure 3.
Figure 3.. Multiple sequence alignment of representative CHH/MIH/GIH proteins from each taxon.
Six conserved cysteine residues are annotated within red boxes.
Figure 4.
Figure 4.. Crustacean CHH/MIH/GIH phylogeny.
The tree was constructed using the maximum-likelihood method from an amino acid multiple sequence alignment. The node labels of each taxon are marked with distinctive colors denoted in the figure inset. Bootstrap support values ( n=1000) are denoted as branch labels.
See this image and copyright information in PMC

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