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. 2016 Mar;5(1):115-118.
doi: 10.1016/j.jshs.2014.12.005. Epub 2015 Apr 18.

Intermittent blood flow restriction does not reduce atrophy following anterior cruciate ligament reconstruction

Erik Iversen  1 , Vibeke Røstad  1 , Arne Larmo  2
Affiliations

Intermittent blood flow restriction does not reduce atrophy following anterior cruciate ligament reconstruction

Erik Iversen et al. J Sport Health Sci. 2016 Mar.

Abstract

Background: A previous study has reported a 50% reduction in disuse atrophy of the quadriceps during the first 14 days after anterior cruciate ligament (ACL) reconstruction. A follow-up trial is needed to confirm these promising results. The present study aims to investigate the effect of an occlusion stimulus on quadriceps atrophy after ACL reconstruction.

Methods: A total of 24 subjects participated in the study. They were randomized into two groups. Starting the 2nd day after surgery, the occlusion group received an occlusion stimulus for 5 min, followed by removal of the occlusive pressure for 3 min. This was repeated five times in one training session, twice daily. During the period of occlusive stimulus, the subjects performed 20 low load exercises for the quadriceps. The control group followed the same exercise protocol, but without the occlusion stimulus. Changes in quadriceps anatomical cross section area (ACSA) were measured using axial magnetic resonance (MR) images at 40% and 50% of the length of the femur.

Results: Both groups had a significant reduction of quadriceps ACSA from 2 days before surgery to 16 days after surgery. During the intervention period, the occlusion group lost 13.8% ± 1.1% (mean ± SEM) and the control group lost 13.1% ± 1.0% of their quadriceps ACSA, respectively. There was no significant difference between the occlusion and control groups with regards to atrophy of the quadriceps muscles.

Conclusion: In conflict with other studies using a similar protocol, application of blood flow restriction the first 14 days after ACL reconstruction did not reduce quadriceps ACSA muscle atrophy measured by MR in a population of athletes.

Keywords: ACL reconstruction; Ascular occlusion; Hypoxia ischemia; Quadriceps atrophy.

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Figures

Fig. 1
Fig. 1
Mean % change in quadriceps anatomical cross sectional area (ACSA).
See this image and copyright information in PMC

References

    1. Akima H., Furukawa T. Atrophy of thigh muscles after meniscal lesions and arthroscopic partial menisectomy. Knee Surg Sports Traumatol Arthrosc. 2005;13:632–637. - PubMed
    1. Dirks M.L., Wall B.T., Snijders T., Ottenbros C.L., Verdijk L.B., van Loon L.J. Neuromuscular electrical stimulation prevents muscle disuse atrophy during leg immobilization in humans. Acta Physiol. 2014;210:628–641. - PubMed
    1. Wall B.T., Dirks M.L., Snijders T., Senden J.M., Dolmans J., van Loon L.J. Substantial skeletal muscle loss occurs during only 5 days of disuse. Acta Physiol. 2014;210:600–611. - PubMed
    1. Wall B.T., van Loon L.J. Nutritional strategies to attenuate muscle disuse atrophy. Nutr Rev. 2013;71:195–208. - PubMed
    1. Campbell E.L., Seynnes O.R., Bottinelli R., McPhee J.S., Atherton P.J., Jones D.A. Skeletal muscle adaptations to physical inactivity and subsequent retraining in young men. Biogerontology. 2013;14:247–259. - PubMed