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. 2016 Dec;5(4):388-390.
doi: 10.1016/j.jshs.2016.10.004. Epub 2016 Oct 21.

BACE1 inhibition as a therapeutic strategy for Alzheimer's disease

Robert Vassar  1
Affiliations

BACE1 inhibition as a therapeutic strategy for Alzheimer's disease

Robert Vassar. J Sport Health Sci. 2016 Dec.
No abstract available

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References

    1. Vassar R., Bennett B.D., Babu-Khan S., Kahn S., Mendiaz E.A., Denis P. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science. 1999;286:735–741. - PubMed
    1. Yan R., Bienkowski M.J., Shuck M.E., Miao H., Tory M.C., Pauley A.M. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. Nature. 1999;402:533–537. - PubMed
    1. Sinha S., Anderson J.P., Barbour R., Basi G.S., Caccavello R., Davis D. Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature. 1999;402:537–540. - PubMed
    1. Hussain I., Powell D., Howlett D.R., Tew D.G., Meek T.D., Chapman C. Identification of a novel aspartic protease (Asp 2) as beta-secretase. Mol Cell Neurosci. 1999;14:419–427. - PubMed
    1. Lin X., Koelsch G., Wu S., Downs D., Dashti A., Tang J. Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein. Proc Natl Acad Sci U S A. 2000;97:1456–1460. - PMC - PubMed