Systemic Inflammation Is Associated With Longitudinal Changes in Cognitive Performance Among Urban Adults

Abstract

Objectives/Background: Systemic inflammation can affect cognitive performance over time. The current study examined associations between systemic inflammation and cognitive performance among African Americans and Whites urban adults, stratifying by sex, and age group and by race. Patients/Methods: Among 1,555-1,719 White and African-American urban adults [Age_base: 30-64y, 2004-2013, mean±SD follow-up time(y): 4.64 ± 0.93y], conducted linear mixed-effects regression models were conducted to test associations of inflammatory markers [C-reactive protein, Erythrocyte Sedimentation Rate (ESR), albumin, iron, and an inflammation composite score (ICS)] with longitudinal cognitive performance. Results: Among key findings, CRP was linked to poorer baseline mental status among younger women (≤50y, γ₀₁ = -0.03 ± 0.01, p = 0.002) and poorer attention in older women (>50y, γ₀₁ = -0.024 ± 0.007, p < 0.004) and African-Americans (γ₀₁ = -0.029 ± 0.008, p < 0.001). ESR was related to faster decline on verbal memory among older men (>50y, γ₁₁ = -0.008 ± 0.003, P = 0.009); with poorer performance on attention tests overall (γ₀₁ = -0.010 ± 0.003, P = 0.003) and among African-Americans (γ₀₁ = -0.013 ± 0.004, P = 0.002); on verbal fluency among older women (>50y,γ₀₁ = -0.037 ± 0.013, P = 0.004) and on executive function: overall (γ₀₁ = +0.62 ± 0.21, P = 0.004), older men (>50y, γ₀₁ = +1.69 ± 0.53, P = 0.001) and African-Americans (γ₀₁ = +0.84 ± 0.28, P = 0.002). Albumin was linked to slower attention decline among older men (>50y, γ₁₁ = +0.329 ± 0.103, P = 0.009), over-time improvement in executive function overall (γ₁₁ = -6.00 ± 2.26, P = 0.008), and better baseline psychomotor speed among African-Americans (γ₀₁ = +0.56 ± 0.19, P = 0.003). Finally, ICS predicted faster decline on visual memory/visuo-constructive abilities among older men (>50y, γ₁₁ = +0.17 ± 0.06, p = 0.003). Conclusion: In sum, strong associations between systemic inflammation and longitudinal cognitive performance were detected, largely among older individuals (>50y) and African-Americans. Randomized trials targeting inflammation are warranted.

Keywords: C-reactive protein (CRP); cognitive performance; inflammation; serum biomarkers; urban adults.

Figure 1

Predictive margins for Trailmaking test B (sec,) by serum albumin levels (g/dL): mixed-effects regression models: total population.