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Review
. 2018 Oct 29;47(21):8030-8056.
doi: 10.1039/c8cs00350e.

Aryne-based strategy in the total synthesis of naturally occurring polycyclic compounds

Hiroshi Takikawa  1 , Arata Nishii, Takahiro Sakai, Keisuke Suzuki
Affiliations
Review

Aryne-based strategy in the total synthesis of naturally occurring polycyclic compounds

Hiroshi Takikawa et al. Chem Soc Rev. .

Abstract

The total syntheses of polycyclic natural products by exploiting an aryne as the key reactive species are reviewed. A short introduction summarizes the basic reactivities of aryne species as well as the methods for its generation. In the main part, early examples and the recent reports (mainly 2012-present) on the use of arynes in multistep syntheses are described.

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