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. 2019 Jan 8;47(D1):D550-D558.
doi: 10.1093/nar/gky1001.

Complex Portal 2018: extended content and enhanced visualization tools for macromolecular complexes

Birgit H M Meldal  1 , Hema Bye-A-Jee  1 , Lukáš Gajdoš  2 , Zuzana Hammerová  2 , Aneta Horácková  2 , Filip Melicher  2 , Livia Perfetto  1 , Daniel Pokorný  2 , Milagros Rodriguez Lopez  1 , Alžbeta Türková  2 , Edith D Wong  3 , Zengyan Xie  4 , Elisabeth Barrera Casanova  1 , Noemi Del-Toro  1 , Maximilian Koch  1   5 , Pablo Porras  1 , Henning Hermjakob  1   6 , Sandra Orchard  1
Affiliations

Complex Portal 2018: extended content and enhanced visualization tools for macromolecular complexes

Birgit H M Meldal et al. Nucleic Acids Res. .

Abstract

The Complex Portal (www.ebi.ac.uk/complexportal) is a manually curated, encyclopaedic database that collates and summarizes information on stable, macromolecular complexes of known function. It captures complex composition, topology and function and links out to a large range of domain-specific resources that hold more detailed data, such as PDB or Reactome. We have made several significant improvements since our last update, including improving compliance to the FAIR data principles by providing complex-specific, stable identifiers that include versioning. Protein complexes are now available from 20 species for download in standards-compliant formats such as PSI-XML, MI-JSON and ComplexTAB or can be accessed via an improved REST API. A component-based JS front-end framework has been implemented to drive a new website and this has allowed the use of APIs from linked services to import and visualize information such as the 3D structure of protein complexes, its role in reactions and pathways and the co-expression of complex components in the tissues of multi-cellular organisms. A first draft of the complete complexome of Saccharomyces cerevisiae is now available to browse and download.

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Figures

Figure 1.
Figure 1.
Screenshot of the details page of Haemoglobin HbA complex (CPX-2158).
Figure 2.
Figure 2.
(A–C) Reactome, PDBe and Gene Expression Atlas tools as integrated in Complex Portal for Hemoglobin HbA complex.
Figure 2.
Figure 2.
(A–C) Reactome, PDBe and Gene Expression Atlas tools as integrated in Complex Portal for Hemoglobin HbA complex.
See this image and copyright information in PMC

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