Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018:1077:389-414.
doi: 10.1007/978-981-13-0947-2_21.

Collagen Type I: A Versatile Biomaterial

Shiplu Roy Chowdhury  1 , Mohd Fauzi Mh Busra  1 , Yogeswaran Lokanathan  1 , Min Hwei Ng  1 , Jia Xian Law  1 , Ude Chinedu Cletus  2 , Ruszymah Binti Haji Idrus  3
Affiliations
Review

Collagen Type I: A Versatile Biomaterial

Shiplu Roy Chowdhury et al. Adv Exp Med Biol. 2018.

Abstract

Collagen type I is the most abundant matrix protein in the human body and is highly demanded in tissue engineering, regenerative medicine, and pharmaceutical applications. To meet the uprising demand in biomedical applications, collagen type I has been isolated from mammalians (bovine, porcine, goat and rat) and non-mammalians (fish, amphibian, and sea plant) source using various extraction techniques. Recent advancement enables fabrication of collagen scaffolds in multiple forms such as film, sponge, and hydrogel, with or without other biomaterials. The scaffolds are extensively used to develop tissue substitutes in regenerating or repairing diseased or damaged tissues. The 3D scaffolds are also used to develop in vitro model and as a vehicle for delivering drugs or active compounds.

Keywords: Biomaterial; Collagen type I; Drug delivery system; Fabrication; In vitro model; Tissue engineering; Tissue substitutes.

PubMed Disclaimer

References

    1. Abou Neel EA, Bozec L, Knowles JC et al (2013) Collagen – emerging collagen based therapies hit the patient. Adv Drug Deliv Rev 65:429–456. https://doi.org/10.1016/j.addr.2012.08.010 - DOI - PubMed
    1. Addad S, Exposito JY, Faye C et al (2011) Isolation, characterization and biological evaluation of jellyfish collagen for use in biomedical applications. Mar Drugs 9:967–983. https://doi.org/10.3390/md9060967 - DOI - PubMed - PMC
    1. Alexandra PM, Rui LR, Rogério PP, Mariana C (2017) Skin tissue models. Academic, London
    1. Amani H, Dougherty WR, Blome-Eberwein S (2006) Use of Transcyte and dermabrasion to treat burns reduces length of stay in burns of all size and etiology. Burns 32(7):828–832. https://doi.org/10.1016/j.burns.2006.04.003 - DOI - PubMed
    1. Anders S, Volz M, Frick H, Gellissen J (2013) A randomized, controlled trial comparing Autologous Matrix-Induced Chondrogenesis (AMIC®) to microfracture: analysis of 1- and 2-year follow-up data of 2 centers. Open Orthop J 3(7):133–143. https://doi.org/10.2174/1874325001307010133 - DOI

LinkOut - more resources