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Editorial
. 2018 Aug 21;138(8):806-808.
doi: 10.1161/CIRCULATIONAHA.118.035186.

Undeniable Evidence That the Adult Mammalian Heart Lacks an Endogenous Regenerative Stem Cell

Affiliations
Editorial

Undeniable Evidence That the Adult Mammalian Heart Lacks an Endogenous Regenerative Stem Cell

Bryan D Maliken et al. Circulation. .
No abstract available

Keywords: Editorials; stem cells.

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Conflict of interest statement

Conflict of Interest Disclosures

J.D.M. received significant research support from the NIH (R37HL60562), however no direct conflicts of interest related to this Editorial are declared.

Comment on

  • Genetic Lineage Tracing of Nonmyocyte Population by Dual Recombinases.
    Li Y, He L, Huang X, Bhaloo SI, Zhao H, Zhang S, Pu W, Tian X, Li Y, Liu Q, Yu W, Zhang L, Liu X, Liu K, Tang J, Zhang H, Cai D, Ralf AH, Xu Q, Lui KO, Zhou B. Li Y, et al. Circulation. 2018 Aug 21;138(8):793-805. doi: 10.1161/CIRCULATIONAHA.118.034250. Circulation. 2018. PMID: 29700121

References

    1. Orlic D, Kajstura J, Chimenti S, Jakoniuk I, Anderson SM, Li B, Pickel J, McKay R, Nadal-Ginard B, Bodine DM, Leri A, Anversa P. Bone marrow cells regenerate infarcted myocardium. Nature. 2001;410:701–705. - PubMed
    1. Beltrami AP, Barlucchi L, Torella D, Baker M, Limana F, Chimenti S, Kasahara H, Rota M, Musso E, Urbanek K, Leri A, Kajstura J, Nadal-Ginard B, Anversa P. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell. 2003;114:763–776. doi: 10.1016/S0092-8674(03)00687-1. - DOI - PubMed
    1. Murry CE, Soonpaa MH, Reinecke H, Nakajima H, Nakajima HO, Rubart M, Pasumarthi KB, Virag JI, Bartelmez SH, Poppa V, Bradford G, Dowell JD, Williams DA, Field LJ. Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature. 2004;428:664–668. doi: 10.1038/nature02446. - DOI - PubMed
    1. Balsam LB, Wagers AJ, Christensen JL, Kofidis T, Weissmann IL, Robbins RC. Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature. 2004;428:668–673. doi: 10.1038/nature02460. - DOI - PubMed
    1. Fisher SA, Doree C, Mathur A, Taggart DP, Martin-Rendon E. Stem cell therapy for chronic ischaemic heart disease and congestive heart failure. Cochrane Database Syst Rev. 2016 doi: 10.1002/14651858.CD007888.pub3. - DOI - PMC - PubMed