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Editorial
. 2018 Aug 14;138(7):692-695.
doi: 10.1161/CIRCULATIONAHA.118.033907.

Heart Disease and Cancer: Are the Two Killers Colluding?

Richard N Kitsis  1 , Jaime A Riquelme  2 , Sergio Lavandero  2   3
Affiliations
Editorial

Heart Disease and Cancer: Are the Two Killers Colluding?

Richard N Kitsis et al. Circulation. .
No abstract available

Keywords: Editorials; SerpinA1 protein, human; ceruloplasmin; fibronectins; heart failure; transplantation, heterotopic.

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Figures

Figure
Figure. Failing heart stimulates colon tumor growth
A, Experimental models (left panel) showed that myocardial infarction-induced heart failure (MI-HF) stimulates pre-cancerous colon tumor growth in APCmin mice. Left ventricular ejection fraction was markedly decreased after myocardial infaction in MI-HF mice compared to sham-operated mice (Sham). MI-HF mice also developed more and larger intestinal polyps than Sham mice. Failing hearts heterotopically (HTx) transplanted to APCmin recipient mice trigger the same tumorigenic effect. In silico studies (middle panel). Exploration strategy identified alpha-1-antitrypsin (SerpinA1), alpha-1-antichymotrypsin (SerpinA3), fibronectin (FN), cerulopasmin (CP), and paraoxonase 1 (PON1) as potential circulating factors responsible for promoting tumorigenesis. In vitro studies (middle panel) showed that Serpin A1/A3 elicited proliferation of the HT-29 cancer cell line. Population studies (right panel) showed that plasma levels of SerpinA1, SerpinA3, FN, CP and PON1 were increased in chronic heart failure (CHF) patients compared to healthy patients. B, Proposed model, whereby post-MI induced HF promotes colon tumor growth. Shared risk factors, such as unhealthy diet, tobacco smoking, obesity, diabetes mellitus and hypertension are potential links between both diseases. Mechanistically, chronic inflammation, oxidative stress, cytokines, angiotensin II and catecholamines are all plausible mediators contributing to this connection as they play a role in both cancer and cardiovascular diseases.
See this image and copyright information in PMC

Comment on

  • Heart Failure Stimulates Tumor Growth by Circulating Factors.
    Meijers WC, Maglione M, Bakker SJL, Oberhuber R, Kieneker LM, de Jong S, Haubner BJ, Nagengast WB, Lyon AR, van der Vegt B, van Veldhuisen DJ, Westenbrink BD, van der Meer P, Silljé HHW, de Boer RA. Meijers WC, et al. Circulation. 2018 Aug 14;138(7):678-691. doi: 10.1161/CIRCULATIONAHA.117.030816. Circulation. 2018. PMID: 29459363

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