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Multicenter Study
. 2018 Oct 25;13(10):e0206403.
doi: 10.1371/journal.pone.0206403. eCollection 2018.

ABO blood types and major outcomes in patients with acute hypoxaemic respiratory failure: A multicenter retrospective cohort study

Emanuele Rezoagli  1   2   3 , Stefano Gatti  1 , Silvia Villa  1 , Giulia Villa  1 , Stefano Muttini  4 , Fabio Rossi  5 , Loredana Faraldi  6 , Roberto Fumagalli  1   6 , Giacomo Grasselli  7   8 , Giuseppe Foti  1   9 , Giacomo Bellani  1   9
Affiliations
Multicenter Study

ABO blood types and major outcomes in patients with acute hypoxaemic respiratory failure: A multicenter retrospective cohort study

Emanuele Rezoagli et al. PLoS One. .

Abstract

Introduction: ABO blood type A was reported to correlate with an increased risk of acute respiratory distress syndrome (ARDS) in white patients with severe sepsis and major trauma compared with patients with other blood types. Information regarding ABO phenotypes and major outcomes in patients with ARDS is unavailable. The primary aim was to determine the relationship between ABO blood type A and intensive care unit (ICU) mortality in patients with acute hypoxemic respiratory failure (AHRF). The secondary aim was to describe the association between ABO blood type A and ICU length of stay (LOS) in this study population.

Methods: In a multicenter, retrospective cohort study, we collected the clinical records of patients admitted from January 2012 to December 2014 in five ICUs of Northern Italy. We included adult white patients admitted to the ICU who were diagnosed with AHRF requiring mechanical ventilation.

Results: The electronic records of 1732 patients with AHRF were reviewed. The proportion of patients with ABO blood type A versus other blood types was 39.9% versus 60.1%. ICU mortality (25%) and ICU LOS (median [interquartile range], 5 [2-12] days) were not different when stratified by ABO blood type (ICU mortality, overall p value = 0.905; ICU LOS, overall p value = 0.609). SAPSII was a positive predictor of ICU mortality (odds ration [OR], 32.80; 95% confidence interval [CI], 18.80-57.24; p < 0.001) and ICU LOS (β coefficient, 0.55; 95% CI, 0.35-0.75; p < 0.001) at multivariate analyses, whereas ABO blood type did not predict ICU outcome when forced into the model.

Conclusion: ABO blood type did not correlate with ICU mortality and ICU LOS in adult patients with AHRF who were mechanically ventilated.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1
Frequency of ICU mortality (A) and ICU length of stay in patients who survived at discharge (B) stratified by ABO blood type. Data in panel A are expressed as frequency (%) and in panel B as box and whiskers plots (1–99 percentile) with outliers (dots).
See this image and copyright information in PMC

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