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Case Reports
. 2019;28(2):193-195.
doi: 10.1159/000494839. Epub 2018 Oct 25.

Nonsteroidal Anti-Inflammatory Drug-Induced Colopathy in a Colorectal Cancer Screening Program

Sanja Borozan  1 , Ljiljana Vuckovic  2 , Brigita Smolovic  3
Affiliations
Case Reports

Nonsteroidal Anti-Inflammatory Drug-Induced Colopathy in a Colorectal Cancer Screening Program

Sanja Borozan et al. Med Princ Pract. 2019.

Abstract

Objective: To present a case of colopathy related to the use of diclofenac in a patient with a positive immunochemical faecal occult blood test (iFOBT) and to discuss the influence of nonsteroidal anti-inflammatory drugs (NSAIDs) on iFOBT specificity.

Clinical presentation and intervention: A colonoscopy in a 56-year-old female presenting with a positive iFOBT revealed diaphragm-like strictures and ulcers in the right colon. While carrying out a detailed retrospective interview, she reported a chronic backache requiring long-term NSAID treatment.

Conclusion: No association has been established between chronic use of NSAID and a false-positive iFOBT. There is no need to stop NSAIDs before performing an iFOBT in a colorectal cancer screening program.

Keywords: Colopathy; Colorectal cancer screening; Diaphragms; Immunochemical faecal occult blood test; Nonsteroidal anti-inflammatory drugs.

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Figures

Fig. 1
Fig. 1
A colonoscopy showing an erosion/ulceration lesion in the right colon.
Fig. 2
Fig. 2
A right-sided concentric diaphragm-like stricture that was passable with a scope accompanied by a mucosal lesion.
See this image and copyright information in PMC

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