Complement-mediated hemolysis of horse erythrocytes treated with equine infectious anemia virus
- PMID: 3036045
- DOI: 10.1007/BF01311334
Complement-mediated hemolysis of horse erythrocytes treated with equine infectious anemia virus
Abstract
Horse erythrocytes treated with equine infectious anemia virus hemagglutinin were found to be lysed after incubation with fresh horse serum at 37 degrees C. Fresh guinea pig serum induced more efficient hemolysis than horse serum. Direct immunofluorescence test revealed the adsorption of complement factors on the surface of the erythrocytes. Calcium and magnesium ions were necessary for the hemolysis to take place. Antibody against equine infectious anemia virus enhanced the virus-induced complement-mediated hemolysis. These observations indicated that the classical pathway of complement activation was responsible for this virus-induced hemolysis and suggest the possibility that virus antigen, anti-viral antibody and complement may play an important role in the genesis of the anemia of horses infected with the equine infectious anemia virus.
Similar articles
-
Phagocytosis of horse erythrocytes treated with equine infectious anemia virus by cultivated horse leukocytes.Arch Virol. 1987;95(1-2):67-77. doi: 10.1007/BF01311335. Arch Virol. 1987. PMID: 3036046
-
Hemagglutination of several strains of equine infectious anemia virus.Arch Virol. 1981;67(1):75-84. doi: 10.1007/BF01314604. Arch Virol. 1981. PMID: 6263225
-
In vitro antibody-dependent enhancement assays are insensitive indicators of in vivo vaccine enhancement of equine infectious anemia virus.Virology. 1999 Jul 5;259(2):416-27. doi: 10.1006/viro.1999.9772. Virology. 1999. PMID: 10388665
-
Cytotoxic T lymphocytes and neutralizing antibody in the control of equine infectious anemia virus.Viral Immunol. 2002;15(4):521-31. doi: 10.1089/088282402320914476. Viral Immunol. 2002. PMID: 12513924 Review. No abstract available.
-
[Equine infectious anemia--recent researches and prospect of the study (author's transl)].Uirusu. 1973 Mar;23(1):1-12. Uirusu. 1973. PMID: 4356439 Review. Japanese. No abstract available.
Cited by
-
Phagocytosis of horse erythrocytes treated with equine infectious anemia virus by cultivated horse leukocytes.Arch Virol. 1987;95(1-2):67-77. doi: 10.1007/BF01311335. Arch Virol. 1987. PMID: 3036046
-
A primary production deficit in the thrombocytopenia of equine infectious anemia.J Virol. 1996 Nov;70(11):7842-50. doi: 10.1128/JVI.70.11.7842-7850.1996. J Virol. 1996. PMID: 8892906 Free PMC article.
-
Mice transgenic for equine cyclin T1 and ELR1 are susceptible to equine infectious anemia virus infection.Retrovirology. 2015 Apr 28;12:36. doi: 10.1186/s12977-015-0163-7. Retrovirology. 2015. PMID: 25928027 Free PMC article.
-
The immunopathogenesis of equine infectious anemia virus.Virus Res. 1994 May;32(2):111-38. doi: 10.1016/0168-1702(94)90038-8. Virus Res. 1994. PMID: 8067050 Free PMC article. Review. No abstract available.
-
Immune-mediated thrombocytopenia in horses infected with equine infectious anemia virus.J Virol. 1991 Nov;65(11):6242-51. doi: 10.1128/JVI.65.11.6242-6251.1991. J Virol. 1991. PMID: 1717720 Free PMC article.