Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Feb;19(1):93-104.
doi: 10.1007/s10238-018-0534-1. Epub 2018 Oct 25.

Myeloid cell-like transcript 2 is related to liver inflammation and the pathogenesis of hepatitis B via the involvement of CD8+T cell activation

Jun-Chi Xu  1   2   3 , Fei Gao  4   5 , Yi-An Liu  1   2 , Xiao-Long Zhang  6 , Hui Chen  1   2   3 , Xiao-Yan Zhu  1   2   3 , Hua-Feng Song  1   2   3 , Feng Qian  1   3 , Ming Li  1   3 , Chen Yang  7   8 , Chuan-Wu Zhu  9   10   11 , Ping Xu  12   13   14
Affiliations

Myeloid cell-like transcript 2 is related to liver inflammation and the pathogenesis of hepatitis B via the involvement of CD8+T cell activation

Jun-Chi Xu et al. Clin Exp Med. 2019 Feb.

Abstract

This study analysed the biological significance of TLT-2 on CD8+T cells in hepatitis B patients and provided a theoretical basis for the potential role of TLT-2 as an immune regulator. Flow cytometry sorting, isobaric tags for relative and absolute quantitation and short hairpin RNAs were used to analyse the function of TLT-2 on CD8+T cells in hepatitis B patients. The TLT-2 expression levels in the acute hepatitis B and chronic hepatitis B groups were significantly higher than that in the healthy control group and were positively correlated with ALT and AST. The CD8+TLT-2+T cells exhibited stronger immune function and greater cell proliferation ability and secreted higher levels of cytokines than the CD8+TLT-2-T cells. An analysis of the proteome differences between the TLT-2+CD8+T and TLT-2-CD8+T cells revealed that TLT-2 affected CD8+T cell activation by regulating Granzyme B expression and by further action on the NF-κB signalling pathway. This study first elucidated the mechanism by which TLT-2 influences the activation of CD8+T cells, improved the understanding of the TLT-2 signalling pathway and clarified the role of the TLT-2+CD8+T cell subset in hepatitis B virus infection. The study proposed a novel subset of CD8+T cells that could be useful for understanding the immune function of patients with hepatitis B and further elucidating the pathogenesis of hepatitis B by analysing changes in this subpopulation with the goal of providing a new target for the treatment of hepatitis B.

Keywords: CD8+T; Cell activation; Costimulation; Inflammation; TLT-2.

PubMed Disclaimer

References

    1. Semin Liver Dis. 1999;19(3):329-38 - PubMed
    1. Nat Med. 2001 May;7(5):530-2 - PubMed
    1. J Exp Med. 2001 Oct 15;194(8):1111-22 - PubMed
    1. Blood. 2002 Nov 15;100(10):3822-4 - PubMed
    1. J Immunol. 2003 Jul 15;171(2):594-9 - PubMed

LinkOut - more resources