Ovarian cancer: Pathogenesis and current recommendations for prophylactic surgery

Abstract

Ovarian cancer is one of the most common gynecologic cancers, and one of the leading causes of cancer-associated female mortality in the world. Currently, no widely accepted pathogenesis is available, which may explain the entire disease. Early detection and primary prevention of ovarian cancer are difficult, mostly due to its heterogeneous nature. Risk factor modification based on epidemiologic data has not significantly reduced the incidence of ovarian cancer. Currently, prophylactic surgical methods have been proposed as the most effective preventive measures for both the high-risk or low-risk populations. Understanding the existing pathogenesis theories and the surgical options available may alter physician’s perspectives and facilitate better decision making.

Keywords: primary prevention; salpingectomy; salpingo-oophorectomy; Ovarian cancer.

Figure 1

The two-pathways theory of ovarian cancer STIC: Serous tubal intraepithelial carcinoma