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. 2018 Jan 25;5(2):156-159.
doi: 10.1002/mdc3.12572. eCollection 2018 Mar-Apr.

Limb Kinetic Apraxia Is an Independent Predictor for Quality of Life in Parkinson's Disease

Tim Vanbellingen  1   2 , Dinah Hofmänner  1 , Stefanie Kübel  1 , Stephan Bohlhalter  1
Affiliations

Limb Kinetic Apraxia Is an Independent Predictor for Quality of Life in Parkinson's Disease

Tim Vanbellingen et al. Mov Disord Clin Pract. .

Abstract

Background: Impaired dexterity is a common symptom in Parkinson's disease (PD) and has been related to limb kinetic apraxia (LKA). LKA negatively influenced activities of daily living (ADL) in PD. However, the impact on quality of life (QoL) remains to be clarified, which was the aim of the current study.

Methods: Eighty nondemented patients with PD and 60 age-matched, sex-matched healthy individuals participated in this study. The 39-item Parkinson's Disease Questionnaire was used to measure QoL. Dexterity was assessed by the coin rotation (CR) task and the ADL-related Dexterity Questionnaire 24. Nonmotor symptoms were monitored with part I of the Movement Disorder Society-Unified Parkinson's Disease Rating Scale, and motor symptoms were measured with parts II and III of the modified Movement Disorder Society-Unified Parkinson's Disease Rating Scale.

Results: Regression analysis revealed that dexterity scores controlled for parkinsonian motor symptoms were a strong and independent predictor of QoL in patients with PD.

Conclusion: The study demonstrated that the strong association of impaired dexterity and QoL is independent of bradykinesia, thereby underscoring the clinical relevance of LKA in PD.

Keywords: Parkinson's disease; dexterity; limb‐kinetic apraxia; quality of life.

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Figures

Figure 1
Figure 1
A,B: Scatter plots present significant partial correlations between dexterity measures (the coin rotation task and the activities of daily living‐related Dexterity Questionnaire 24) and the Parkinson Disease Questionnaire 39 (PDQ‐39) controlled for motor parkinsonian symptoms (Movement Disorder Society‐Unified Parkinson's Disease Rating Scale part III).
See this image and copyright information in PMC

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