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. 2016 Nov 1;4(3):403-405.
doi: 10.1002/mdc3.12448. eCollection 2017 May-Jun.

Consistency of "Probable RBD" Diagnosis with the RBD Screening Questionnaire: A Follow-up Study

Ambra Stefani  1 , Philipp Mahlknecht  1 , Klaus Seppi  1 , Michael Nocker  1 , Katherina J Mair  1 , Anna Hotter  1 , Heike Stockner  1 , Johann Willeit  1 , Stefan Kiechl  1 , Gregor Rungger  2 , Arno Gasperi  2 , Werner Poewe  1 , Birgit Högl  1
Affiliations

Consistency of "Probable RBD" Diagnosis with the RBD Screening Questionnaire: A Follow-up Study

Ambra Stefani et al. Mov Disord Clin Pract. .

Abstract

Introduction: The aim of this study was to evaluate the consistency of "probable RBD" diagnosis with the RBD screening questionnaire (RBDSQ) assessed 2 years apart in a population-based study.

Methods: Probable RBD was assessed by RBDSQ in 2008 and in 2010 in the Bruneck Study Cohort, with participants aged ≥60 years.

Results: A total of 437 participants completed the RBDSQ in 2008 and 2010. There were 29 (6.6%) and 23 (5.3%) participants with probable RBD in 2008 and in 2010, respectively. Only eight (1.8%) screened positive on both occasions. RBDSQ values 2 years apart showed low correlation with each other (Spearman rank coefficient r = 0.348, P < 0.001) and low agreement (intraclass correlation coefficient 0.388, P < 0.001).

Conclusions: We found low agreement between the two assessments. Possible explanations are the fluctuation of untreated RBD expression and the poor utility of the RBDSQ to detect RBD in the general population. Until further PSG validation of the RBDSQ in population-based studies, investigators must be aware of the inherent uncertainty of questionnaire-based RBD diagnosis.

Keywords: Lewy body disease; Parkinson's disease; REM‐sleep behavior disorder; nonmotor symptom; risk marker.

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Figures

Figure 1
Figure 1
RBDSQ values (2008 and 2010) of the 44 subjects positive in at least one occasion. The horizontal dotted line represents the cut‐off for probable RBD with the RBDSQ, corresponding to 5 points. On the left side the 2008 scores are represented, and on the right side the 2010 scores. Grey lines represent subjects who screened positive (RBDSQ ≥5) on one of two occasions; red lines represent subjects who screened positive both times (n = 8). Each line reflects either one subject or more subjects showing the same RBDSQ on both occasions. The lines without asterisks represent one subject; for lines with asterisks, the number of asterisks reflects the number of subjects represented by the specific line. RBDSQ, REM sleep behavior disorder (RBD) screening questionnaire.
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