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. 2015 Jun 4;2(3):249-252.
doi: 10.1002/mdc3.12165. eCollection 2015 Sep.

Serum Ferritin Levels in Parkinson's Disease Patients with and without Restless Legs Syndrome

Maria-Lucia Muntean  1   2 , Friederike Sixel-Döring  1   3 , Claudia Trenkwalder  1   4
Affiliations

Serum Ferritin Levels in Parkinson's Disease Patients with and without Restless Legs Syndrome

Maria-Lucia Muntean et al. Mov Disord Clin Pract. .

Abstract

Background: The frequency of RLS in Parkinson's disease (PD) patients has been reported to be between 10% and 26%. Several hypotheses have sought to link these two diseases; however, the pathophysiology of RLS in PD patients has yet to be completely defined. Many patients with idiopathic RLS have low serum ferritin levels, which negatively influence RLS symptomatology. Our objective was to investigate the role of iron deficiency in PD patients with and without RLS.

Methods: We consecutively included 42 PD inpatients undergoing pharmacological treatment. Patients with anemia, renal insufficiency, or polyneuropathy were excluded from the study. The control group consisted of 42 PD inpatients without RLS (PD-nonRLS), matched for age and severity of PD. RLS was diagnosed clinically according to diagnostic criteria. Serum ferritin levels were measured at admission for all patients.

Results: Mean serum ferritin values were 142.20 ± 91.17 ng/dL for PD patients with RLS (PD+RLS) and 160.65 ± 142.57 ng/dL in PD-nonRLS (P = 0.704). There was no difference concerning the total dopaminergic dose (levodopa equivalent dose) between PD+RLS and PD-nonRLS patients (828.22 ± 389.02 vs. 775.32 ± 324.69 mg; P = 0.501). The frequency of dopamine agonist (DA) use did not differ between the two groups (P = 0.306).

Conclusions: There were no significant differences in serum ferritin levels between PD+RLS and PD-nonRLS in our study. This suggests a different pathophysiology of RLS in PD patients, where iron deficiency is not necessarily observed. DA use was not found to be associated with the occurrence of RLS symptoms.

Keywords: Parkinson's disease; ferritin; iron; restless legs syndrome (RLS).

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Figure 1
Figure 1
Box‐plot representation of the serum ferritin levels.
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References

    1. Gjerstad MD, Tysnes OB, Larsen JP. Increased risk of leg motor restlessness but not RLS in early Parkinson disease. Neurology 2011;77:1941–1946. - PubMed
    1. Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisir J. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med 2003;4:101–119. - PubMed
    1. Krishnan PR, Bhatia M, Behari M. Restless legs syndrome in Parkinson's disease: a case‐controlled study. Mov Disord 2003;18:181–185. - PubMed
    1. Ondo WG, Vuong KD, Jankovic J. Exploring the relationship between Parkinson disease and restless legs syndrome. Arch Neurol 2002;59:421–424. - PubMed
    1. Sixel‐Doring F, Trautmann E, Mollenhauer B, Trenkwalder C. Age, drugs, or disease: what alters the macrostructure of sleep in Parkinson's disease? Sleep Med 2012;13:1178–1183. - PubMed

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