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Case Reports
. 2016 Mar 31;3(3):288-291.
doi: 10.1002/mdc3.12271. eCollection 2016 May-Jun.

Malignant Subthalamic Nucleus-Deep Brain Stimulation Withdrawal Syndrome in Parkinson's Disease

Roopa Rajan  1 , Syam Krishnan  1 , Krishna Kumar Kesavapisharady  1 , Asha Kishore  1
Affiliations
Case Reports

Malignant Subthalamic Nucleus-Deep Brain Stimulation Withdrawal Syndrome in Parkinson's Disease

Roopa Rajan et al. Mov Disord Clin Pract. .

Abstract

Abrupt cessation of STN-DBS is an under-recognized cause of life-threatening akinetic crisis in Parkinson's disease (PD) and can present as a movement disorder emergency. We report on 2 patients who survived severe and prolonged akinetic crisis after abrupt cessation of STN stimulation for PD (malignant STN-DBS withdrawal syndrome). We discuss the clinical similarities and possible differences in pathophysiology from the akinetic crisis in medically-treated PD. Although early implantable pulse generator (IPG) replacement is the definitive treatment, medical and economic considerations may preclude early surgery and strategies for medical management assume importance. We reflect upon the socioeconomic concerns surrounding DBS in countries lacking health care coverage and the need for user-independent monitors and indicators of low IPG battery status.

Keywords: Parkinson's disease; akinetic crisis; implantable pulse generator depletion; malignant STN‐DBS withdrawal syndrome; parkinsonism‐hyperpyrexia syndrome.

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References

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