Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Dec 24;3(2):168-172.
doi: 10.1002/mdc3.12279. eCollection 2016 Mar-Apr.

Nocturia in Patients With Parkinson's Disease

Matthew Smith  1 , Jai Seth  1 , Amit Batla  2 , Johann Hofereiter  1 , Kailash P Bhatia  2 , Jalesh N Panicker  1
Affiliations

Nocturia in Patients With Parkinson's Disease

Matthew Smith et al. Mov Disord Clin Pract. .

Abstract

Background: Waking up from sleep more than once to pass urine, known as nocturia, is an important nonmotor symptom in Parkinson's disease (PD). Very little is known about the cause for nocturia. The aim of this work was to evaluate lower urinary tract (LUT) symptoms in patients with PD reporting nocturia using standardized validated questionnaires and bladder diaries and to assess the impact of nocturia on quality of life and sleep.

Methods: Twenty-three consecutive patients with PD (17 males, 6 females; mean age: 68.5 years; range, 50-85) referred to a specialist uro-neurology clinic reporting nocturia according to the International Continence Society definition were included. Patients measured their daily fluid intake, urinary output per void, and recorded these with the timing of voids on a 3-day bladder diary. Standardized questionnaires were used to assess LUT symptoms (Urinary Symptom Profile, International Prostate Symptom Score, and Qualiveen Short Form) and sleep quality (Parkinson's Disease Sleep Scale).

Results: Mean duration of PD was 10.1 years, and mean severity on H & Y scale was 3.0 (range, 1.0-5.0). Median duration of LUT symptoms was 6.0 years. Mean night-time urinary frequency was 3.5 (range, 1.0-7.3), and mean nocturnal maximum voided volume was 242 mL. Mean Nocturnal Polyuria Index (NPi) was 0.4 (range, 0.13-0.75), and 13 patients (56.5%) had nocturnal polyuria (NPi > 0.33). Patients with nocturnal polyuria reported more-severe LUT symptoms that impacted quality of life and sleep.

Conclusions: In this preliminary study, nocturnal polyuria seems to be common in patients with PD reporting nocturia and appears to affect quality of life and sleep, though this was not statistically significant. The bladder diary is an essential tool in the assessment of nocturia in patients with PD.

Keywords: Parkinson's disease; nocturia; nocturnal polyuria; sleep.

PubMed Disclaimer

References

    1. Chaudhuri KR, Martinez‐Martin P, Schapira AH, et al. International multicenter pilot study of the first comprehensive self‐completed nonmotor symptoms questionnaire for Parkinson's disease: the NMSQuest study. Mov Disord 2006;21:916–923. - PubMed
    1. Weiss JP, Wein AJ, van Kerrebroeck P, et al. Nocturia: new directions. Neurourol Urodyn 2011;30:700–703. - PubMed
    1. Cornu JN, Abrams P, Chapple CR, Dmochowski R, Fitzgerald M, Tikkinen KA, Abrams P. A contemporary assessment of nocturia: definition, epidemiology, pathophysiology, and management—a systematic review and meta‐analysis. Eur Urol 2012;62:877–890. - PubMed
    1. Winge K, Fowler CJ. Bladder dysfunction in Parkinsonism: mechanisms, prevalence, symptoms, and management. Mov Disord 2006;21:737–745. - PubMed
    1. Batla A, Panicker JN. Lower urinary tract dysfunction in Parkinson's disease and multiple system atrophy. Lead Opin Urol 2012;2:20–23.

LinkOut - more resources