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Review
. 2018 Oct 1:2018:3725837.
doi: 10.1155/2018/3725837. eCollection 2018.

Current Role of Chemotherapy in Nonmetastatic Nasopharyngeal Cancer

Tapesh Bhattacharyya  1 , Geethu Babu  2 , Cessal Thommachan Kainickal  2
Affiliations
Review

Current Role of Chemotherapy in Nonmetastatic Nasopharyngeal Cancer

Tapesh Bhattacharyya et al. J Oncol. .

Abstract

Nasopharyngeal carcinoma is highly radio- and chemosensitive tumor with its unique clinical and biological behavior. Treatment of stage I disease is radical radiotherapy alone. For stage II disease treatment is radiotherapy with or without chemotherapy. The standard of care for locally advanced nasopharyngeal cancer (stages III-IVB) is concurrent chemoradiation. Optimum timing and sequence of chemotherapy are not yet well-defined. The role of adjuvant and induction chemotherapy is debatable. Here we are going to highlight the role of chemotherapy in nasopharyngeal carcinoma, its benefit, and controversies regarding timing and sequences.

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References

    1. Vokes E. E., Liebowitz D. N., Weichselbaum R. R. Nasopharyngeal carcinoma. The Lancet. 1997;350(9084):1087–1091. doi: 10.1016/S0140-6736(97)07269-3. - DOI - PubMed
    1. Baujat B., Audry H., Bourhis J., et al. Chemotherapy in locally advanced nasopharyngeal carcinoma: an individual patient data meta-analysis of eight randomized trials and 1753 patients. International Journal of Radiation Oncology, Biology, Physics. 2006;64(1):47–56. - PubMed
    1. Zhang L., Chen Q.-Y., Liu H., Tang L.-Q., Mai H.-Q. Emerging treatment options for nasopharyngeal carcinoma. Drug Design, Development and Therapy. 2013;7:37–52. doi: 10.2147/dddt.s30753. - DOI - PMC - PubMed
    1. Lee A. W. M., Sze W. M., Au J. S. K., et al. Treatment results for nasopharyngeal carcinoma in the modern era: the Hong Kong experience. International Journal of Radiation Oncology, Biology, Physics. 2005;61(4):1107–1116. doi: 10.1016/j.ijrobp.2004.07.702. - DOI - PubMed
    1. Lee N., Harris J., Garden A. S., et al. Intensity-modulated radiation therapy with or without chemotherapy for nasopharyngeal carcinoma: radiation therapy oncology group phase II trial 0225. Journal of Clinical Oncology. 2009;27(22):3684–3690. doi: 10.1200/JCO.2008.19.9109. - DOI - PMC - PubMed

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