Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Jun;4(2):158-165.
doi: 10.1007/s40778-018-0130-z. Epub 2018 Apr 16.

Molecular Moirai: Long Noncoding RNA Mediators of HSC Fate

Nathaniel Magilnick, Mark P Boldin

Molecular Moirai: Long Noncoding RNA Mediators of HSC Fate

Nathaniel Magilnick et al. Curr Stem Cell Rep. 2018 Jun.

Abstract

Purpose of review: Hematopoiesis is an ordered developmental process that requires dynamic regulation to warrant proper response to physiological challenges and prevent malignancies. Long noncoding RNAs are emerging as key, multi-faceted regulators of gene expression. This review explores the function of lncRNAs in the control of HSC homeostasis and hematopoietic differentiation.

Recent findings: Multiple lncRNAs have been implicated in maintaining HSC stemness and enabling progenitors to carry out the correct programs of lineage differentiation. Specific lncRNAs have been identified that regulate the differentiation of multipotent progenitors into terminally differentiated blood cells. These lncRNAs predominantly act by assisting master regulators that drive specific differentiation programs, either by enhancing or repressing the transcription of particular genomic loci.

Summary: Long noncoding RNAs contribute to the correct differentiation and maturation of various hematopoietic lineages by assisting with the activation of transcriptional programs in a time- and cell-dependent manner.

Keywords: HSC; Hematopoiesis; cell fate; differentiation; long noncoding RNA.

PubMed Disclaimer

Conflict of interest statement

Compliance with Ethical Standards Conflict of Interest Nathaniel Magilnick and Mark P. Boldin declare that they have no conflict of interest.

Figures

Figure 1
Figure 1. Control of mammalian hematopoiesis by lncRNA
Long noncoding RNAs play key roles in maintenance of HSC homeostasis and development of terminally differentiated blood cells during hematopoiesis. LncRNA genes are listed in red. HSC, hematopoietic stem cell; MPP, multipotent progenitor cell; CMP, common myeloid progenitor; CLP, common lymphoid progenitor; MEP, megakaryocyte erythroid progenitor; GMP, granulocyte macrophage progenitor; EB, erythroblast; MK, megakaryocyte; GC, granulocyte; MF, macrophage; DC, dendritic cell; NK, natural killer; PLT, platelets; RBC, red blood cells.
See this image and copyright information in PMC

References

    1. Morrison JV. Kerostasia, The Dictates of Fate, and the Will of Zeus in the Iliad. Arethusa. 1997;30:276–96.
    1. Orkin SH, Zon LI. Hematopoiesis: an evolving paradigm for stem cell biology. Cell. 2008;132(4):631–44. doi: 10.1016/j.cell.2008.01.025. - DOI - PMC - PubMed
    1. Cabezas-Wallscheid N, Eichwald V, de Graaf J, Lower M, Lehr HA, Kreft A, et al. Instruction of haematopoietic lineage choices, evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1-ETO mouse model. EMBO molecular medicine. 2013;5(12):1804–20. doi: 10.1002/emmm.201302661. - DOI - PMC - PubMed
    1. Deveson IW, Hardwick SA, Mercer TR, Mattick JS. The Dimensions, Dynamics, and Relevance of the Mammalian Noncoding Transcriptome. Trends in genetics : TIG. 2017;33(7):464–78. doi: 10.1016/j.tig.2017.04.004. - DOI - PubMed
    1. Rinn JL, Chang HY. Genome regulation by long noncoding RNAs. Annual review of biochemistry. 2012;81:145–66. doi: 10.1146/annurev-biochem-051410-092902. - DOI - PMC - PubMed

LinkOut - more resources