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. 2020 Aug 13;75(7):1414-1422.
doi: 10.1093/geronb/gby112.

Loneliness and Risk of Dementia

Angelina R Sutin  1 , Yannick Stephan  2 , Martina Luchetti  1 , Antonio Terracciano  3
Affiliations

Loneliness and Risk of Dementia

Angelina R Sutin et al. J Gerontol B Psychol Sci Soc Sci. .

Abstract

Objective: The present study tests whether loneliness is associated with risk of dementia in the largest sample to date and further examines whether the association is independent of social isolation, a related but independent component of social integration, and whether it varies by demographic factors and genetic vulnerability.

Method: Participants from the Health and Retirement Study (N = 12,030) reported on their loneliness, social isolation, and had information on clinical, behavioral, and genetic risk factors. Cognitive status was assessed at baseline and every 2 years over a 10-year follow-up with the modified Telephone Interview for Cognitive Status (TICSm). A TICSm score of 6 or less was indicative of dementia.

Results: Cox proportional hazards regression indicated that loneliness was associated with a 40% increased risk of dementia. This association held controlling for social isolation, and clinical, behavioral, and genetic risk factors. The association was similar across gender, race, ethnicity, education, and genetic risk.

Discussion: Loneliness is associated with increased risk of dementia. It is one modifiable factor that can be intervened on to reduce dementia risk.

Keywords: Dementia risk; Loneliness; Psychosocial risk factors; Social isolation.

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References

    1. Alzheimer’s Association (2017). 2017 Alzheimer’s disease facts and figures. Alzheimer’s & Dementia, 13, 325–373. doi:10.1016/j.jalz.2017.02.001 - PubMed
    1. Beutel M. E., Klein E. M., Brähler E., Reiner I., Jünger C., Michal M.,…Tibubos A. N (2017). Loneliness in the general population: Prevalence, determinants and relations to mental health. BMC Psychiatry, 17, 97. doi:10.1186/s12888-017-1262-x - PMC - PubMed
    1. Böger A., & Huxhold O (2018). Do the antecedents and consequences of loneliness change from middle adulthood into old age?Developmental Psychology, 54, 181–197. doi:10.1037/dev0000453 - PubMed
    1. Brown E. G., Gallagher S., & Creaven A. M (2018). Loneliness and acute stress reactivity: A systematic review of psychophysiological studies. Psychophysiology, 55, e13031. doi:10.1111/psyp.13031 - PubMed
    1. Cacioppo J. T., & Cacioppo S (2014). Social relationships and health: The toxic effects of perceived social isolation. Social and Personality Psychology Compass, 8, 58–72. doi:10.1111/spc3.12087 - PMC - PubMed

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